(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt

Modify Date: 2024-02-02 10:32:14

(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt structure	Common Name	(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt
	CAS Number	102805-45-8	Molecular Weight	3342.204
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄₈H₂₃₉ClN₄₄O₄₂	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of (p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt

[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3].

Name	L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide
Synonym	More Synonyms

Description	[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	IC50: 125.8 nM (VIP receptor)[1]
References	[1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86. [2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7. [3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₄₈H₂₃₉ClN₄₄O₄₂
Molecular Weight	3342.204
Exact Mass	3339.760742
PSA	1453.69000
LogP	-4.01
Index of Refraction	1.657
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog.

Am. J. Physiol. 269(4 Pt 2) , H1467-72, (1995)

We used three vasoactive intestinal polypeptide (VIP) antagonists, VIP-(10-28), [p-Cl-D-Phe6,Leu17]VIP, and NT-VIP, to evaluate the role of VIP as a mediator of vagally induced tachycardia in chloralo...

Pituitary adenylate cyclase-activating peptide stimulates cyclic AMP accumulation in UMR 106 osteoblast-like cells.

J. Endocrinol. 149 , 287, (1996)

Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) share 68% homology and function as neurotransmitters or neuroendocrine factors. Although VIP immunoreacti...

Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate.

Cardiovasc. Res. 32(5) , 846-53, (1996)

To determine the effects of vasoactive intestinal peptide, released from the right and left vagal nerves, on ventricular contraction, relaxation, and heart rate.The muscarinic and beta-adrenergic rece...

L-Aspartamide, L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutam inyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-

L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L -alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide

6-(4-Chloro-D-Phenylalanine)-17-L-Leucine-Vasoactive Intestinaloctacosapeptide (Swine)

(p-Chloro-D-Phe6,Leu17)-VIP

[4ClDPhe6,Leu17] VIP