Intermedine

Modify Date: 2024-01-02 14:14:51

Intermedine Structure
Intermedine structure
Common Name Intermedine
CAS Number 10285-06-0 Molecular Weight 299.36300
Density 1.26g/cm3 Boiling Point 463.3ºC at 760mmHg
Molecular Formula C15H25NO5 Melting Point N/A
MSDS N/A Flash Point 234ºC

 Use of Intermedine


(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs)[1].

 Names

Name intermedine
Synonym More Synonyms

 Intermedine Biological Activity

Description (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs)[1].
Related Catalog
In Vitro (+)-Intermedine (1.1-30 μM; 24 hours) exhibits significant cytotoxicity at 30 μM and reduces cell viability in a concentration dependent manner in neural progenitor cells (NPCs)[1]. (+)-Intermedine showsno differentiation impairment[1]. Cell Cytotoxicity Assay[1] Cell Line: Neural progenitor cells (NPCs) Concentration: 1.1, 3.3, 10, 30 μM Incubation Time: 24 hours Result: Exhibited significant cytotoxicity at 30 μM and reduced cell viability in a concentration dependent manner.
References

[1]. Yan Zhang, et al. Analysis of pyrrolizidine alkaloids in Eupatorium fortunei Turcz. and their in vitro neurotoxicity. Food Chem Toxicol. 2021 May;151:112151.

 Chemical & Physical Properties

Density 1.26g/cm3
Boiling Point 463.3ºC at 760mmHg
Molecular Formula C15H25NO5
Molecular Weight 299.36300
Flash Point 234ºC
Exact Mass 299.17300
PSA 90.23000
Vapour Pressure 1.57E-10mmHg at 25°C
Index of Refraction 1.567

 Safety Information

RIDADR UN 1544
Packaging Group III
Hazard Class 6.1(b)

 Synonyms

[(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate
Intermedina [INN-Spanish]
Butanoic acid,2,3-dihydroxy-2-(1-methylethyl)-,((1R,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester,(2S,3R)
9-(+)-Trachelanthylretronecine
lycopsamine
Intermedine
Intermedinum [INN-Latin]
[(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2s,3r)-2,3-dihydroxy-2-(propan-2-yl)butanoate
Intermedina
Intermedinum
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