10285-06-0

10285-06-0 structure

Name: Intermedine
Chemical Name: intermedine
CAS Number: 10285-06-0
Molecular Formula: C₁₅H₂₅NO₅
Molecular Weight: 299.36300
Catalog: Research Areas Neurological Disease
Create Date: 2017-04-17 08:16:56
Modify Date: 2024-01-02 14:14:51
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs)[1].

Name	intermedine
Synonyms	[(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate Intermedina [INN-Spanish] Butanoic acid,2,3-dihydroxy-2-(1-methylethyl)-,((1R,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester,(2S,3R) 9-(+)-Trachelanthylretronecine lycopsamine Intermedine Intermedinum [INN-Latin] [(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2s,3r)-2,3-dihydroxy-2-(propan-2-yl)butanoate Intermedina Intermedinum

Description	(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	(+)-Intermedine (1.1-30 μM; 24 hours) exhibits significant cytotoxicity at 30 μM and reduces cell viability in a concentration dependent manner in neural progenitor cells (NPCs)[1]. (+)-Intermedine showsno differentiation impairment[1]. Cell Cytotoxicity Assay[1] Cell Line: Neural progenitor cells (NPCs) Concentration: 1.1, 3.3, 10, 30 μM Incubation Time: 24 hours Result: Exhibited significant cytotoxicity at 30 μM and reduced cell viability in a concentration dependent manner.
References	[1]. Yan Zhang, et al. Analysis of pyrrolizidine alkaloids in Eupatorium fortunei Turcz. and their in vitro neurotoxicity. Food Chem Toxicol. 2021 May;151:112151.