CMP-5 hydrochloride
Modify Date: 2024-10-07 19:40:18
CMP-5 hydrochloride structure
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Common Name | CMP-5 hydrochloride | ||
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| CAS Number | 1030021-40-9 | Molecular Weight | 351.872 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H22ClN3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CMP-5 hydrochlorideCMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation. |
| Name | 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation. |
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| References | References 1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C21H22ClN3 |
|---|---|
| Molecular Weight | 351.872 |
| Exact Mass | 351.150238 |
| 9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-, hydrochloride (1:1) |
| 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride (1:1) |