1030021-40-9

1030021-40-9 structure

Name: CMP-5 hydrochloride
Chemical Name: 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride (1:1)
CAS Number: 1030021-40-9
Molecular Formula: C₂₁H₂₂ClN₃
Molecular Weight: 351.872
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2020-01-12 14:32:49
Modify Date: 2024-10-07 19:40:18
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.

Name	1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride (1:1)
Synonyms	9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-, hydrochloride (1:1) 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride (1:1)

Description	CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
References	References 1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43. View Related Products by Target Histone Methyltransferase (HMTase)