Kinetensin

Modify Date: 2024-01-02 12:36:52

Kinetensin Structure
Kinetensin structure
 Common Name Kinetensin
CAS Number 103131-69-7 Molecular Weight 1172.38000
Density 1.41 g/cm3 Boiling Point N/A
Molecular Formula C56H85N17O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Kinetensin


Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

 Names

Name Kinetensin (human)
Synonym More Synonyms

 Kinetensin Biological Activity

Description Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
Related Catalog
Target

Neurotensin Receptor[1]
In Vitro The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2].
In Vivo Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].
Cell Assay Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2].
Animal Admin Rats[2] Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5x2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2].
References

[1]. Mogard MH, et al. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8.

[2]. Sydbom A, et al. Stimulation of histamine release by the peptide kinetensin. Agents Actions. 1989 Apr;27(1-2):68-71.

 Chemical & Physical Properties

Density 1.41 g/cm3
Molecular Formula C56H85N17O11
Molecular Weight 1172.38000
Exact Mass 1171.66000
PSA 460.04000
LogP 4.33470
Index of Refraction 1.661
Storage condition 2~8°C

 Safety Information

Hazard Codes F+
Safety Phrases 22-24/25
WGK Germany 3.0

 Synonyms

nrp
h-ile-ala-arg-arg-his-pro-tyr-phe-leu-oh
ile-ala-arg-arg-his-pro-tyr-phe-leu
iarrhpyfl
kinetensin
neurotensin-related peptide
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Related Compounds: More...
kinetensin
123496-28-6
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