![]() sodium,[5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl hydrogen phosphate structure
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Common Name | sodium,[5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl hydrogen phosphate | ||
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CAS Number | 103226-10-4 | Molecular Weight | 348.15400 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C9H11FN2NaO8P | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
![]() ![]() GHS07, GHS08 |
Signal Word | Warning |
Name | sodium,[5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl hydrogen phosphate |
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Synonym | More Synonyms |
Molecular Formula | C9H11FN2NaO8P |
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Molecular Weight | 348.15400 |
Exact Mass | 348.01300 |
PSA | 163.98000 |
Symbol |
![]() ![]() GHS07, GHS08 |
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Signal Word | Warning |
Hazard Statements | H302-H312-H332-H351 |
Precautionary Statements | P280 |
Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | Xn: Harmful; |
Risk Phrases | 20/21/22-40 |
Safety Phrases | 22-36/37/39 |
RIDADR | NONH for all modes of transport |
Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.
PLoS ONE 10(4) , e0123076, (2015) Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are still in debate. In addition to clinical studies, a priori experimental approaches are needed. Thymidylate sy... |
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Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.
Acta Crystallogr. D Biol. Crystallogr. 67 , 60-66, (2011) Thymidylate synthase (TS) is a well validated target in cancer chemotherapy. Here, a new crystal form of the R163K variant of human TS (hTS) with five subunits per asymmetric part of the unit cell, al... |
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Novel chemical strategies for thymidylate synthase inhibition.
Curr. Med. Chem. 12 , 191-202, (2005) Thymidylate synthase (TS) is a well-validated target for cancer chemotherapy. TS was established as the principal target of the widely used anticancer drug 5-fluorouracil (5FU). The 5FU metabolite FdU... |
FdUMP |
5-Fluoro-2 inverted exclamation marka-deoxyuridine 5 inverted exclamation marka-monophosphate sodium salt |
5-Fluoro-2`-deoxyuridine 5`-Monophosphate Disodium Salt |
disodium 5-fluoro-2'-deoxyuridylate |