Niclofolan

Modify Date: 2024-01-02 16:32:55

Niclofolan Structure
Niclofolan structure
Common Name Niclofolan
CAS Number 10331-57-4 Molecular Weight 345.092
Density 1.7±0.1 g/cm3 Boiling Point 424.9±45.0 °C at 760 mmHg
Molecular Formula C12H6Cl2N2O6 Melting Point N/A
MSDS N/A Flash Point 210.8±28.7 °C

 Use of Niclofolan


Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection[1][2][3].

 Names

Name 4-chloro-2-(5-chloro-2-hydroxy-3-nitrophenyl)-6-nitrophenol
Synonym More Synonyms

 Niclofolan Biological Activity

Description Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection[1][2][3].
Related Catalog
In Vitro Niclofolan (0.12 mg/mL, 60 min) is effective against Gyrodactylus sp. under in vitro conditions[3]. Cell Viability Assay[3] Cell Line: Gyrodactylus sp. (parasite) Concentration: 0.12 mg/mL Incubation Time: 60 min Result: Reduced the number of live Gyrodactylus sp. By 100%.
In Vivo Niclofolan (2 mg/kg, intramuscular injection) is effective against fasciola hepatica infected sheep[2]. Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats[4]. Animal Model: fasciola hepatica infected sheep[2] Dosage: 2 mg/kg Administration: Intramuscular injection Result: Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection. Animal Model: Rats infected with P.iloktsuenesis[4] Dosage: 1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times. Administration: Oral gavage Result: Reduced the worms in rats.
References

[1]. T Eckhardt, Treatment of human fascioliasis with niclofolan. Gastroenterology. 1981 Oct; 81(4):795-8.

[2]. B H Ali, T Hassan, et al. The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. J Vet Pharmacol Ther. 1985 Dec;8(4):398-403.

[3]. Santamarina M. T., et al. Anthelmintic treatment against Gyrodactylus sp. infecting rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms, 1991 10(1): 39-43.

[4]. Rim H J, et al. Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis. The Korean Journal of Parasitology, 1976, 14(2): 140-146.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 424.9±45.0 °C at 760 mmHg
Molecular Formula C12H6Cl2N2O6
Molecular Weight 345.092
Flash Point 210.8±28.7 °C
Exact Mass 343.960297
PSA 132.10000
LogP 3.97
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.706

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DV5075000
CHEMICAL NAME :
(1,1'-Biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-
CAS REGISTRY NUMBER :
10331-57-4
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C12-H6-Cl2-N2-O6
MOLECULAR WEIGHT :
345.10
WISWESSER LINE NOTATION :
WNR DQ CG ER BQ CG ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 4,525,1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 4,525,1971

 Safety Information

Hazard Codes C
HS Code 2907299090

 Customs

HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

 Synonyms

Bayer 9015
EINECS 233-720-0
ME 3625
Bilevon M
5,5'-dichloro-3,3'-dinitro-2,2'-biphenyldiol
5,5'-dichloro-3,3'-dinitrobiphenyl-2,2'-diol
Niclofolanum [INN-Latin]
Niclofolano [INN-Spanish]
5,5'-Dichloro-3,3'-dinitro-[1,1'-biphenyl]-2,2'-diol
Niclofolan
BAY 9015
Menichlopholan
2,2'-Dihydroxy-3,3'-dinitro-5,5'-dichlor-diphenyl