D-Luciferin (sodium salt)
D-Luciferin (sodium salt) structure
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Common Name | D-Luciferin (sodium salt) | ||
|---|---|---|---|---|
| CAS Number | 103404-75-7 | Molecular Weight | 302.305 | |
| Density | N/A | Boiling Point | 473.7ºC at 760mmHg | |
| Molecular Formula | C11H7N2NaO3S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 240.3ºC | |
Use of D-Luciferin (sodium salt)D-Luciferin sodium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | D-Luciferin sodium salt monohydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | D-Luciferin sodium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects. |
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| Related Catalog | |
| In Vitro | D-luciferin is the natural substrate of the enzyme luciferase (Luc), that catalyzes the production of the typical yellowgreen light of fireflies.The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging[1]. |
| In Vivo | Bioluminescence imaging (BLI) using the firefly luciferase (Fluc) as a reporter gene and D-luciferin as a substrate is currently the most widely employed technique. The total signal intensity is plotted against the time after D-luciferin injection to generate a time-intensity curve. In addition to the peak signal, the signals at fixed time points (5, 10, 15, and 20 min) after D-luciferin injection are determined as alternatives to the peak signal. The signal in a given time-intensity curve is normalized for the peak signal in the curve to represent the pattern of temporal changes after D-luciferin injection[2]. |
| Animal Admin | Mice[2] In vivo BLI is performed using a cooled charge-coupled device camera system (IVIS Imaging System 100) 3, 5, 7, 10, 12, 14, 19, 21, 24, and 28 days after the inoculation of HCT116-Luc cells. Mice are injected with 75 mg/kg D-luciferin in 100 L of phosphate-buffered saline subcutaneously near the scapula and were placed in the light-tight chamber of the imaging system under isoflurane anesthesia. Beginning 5 min after injection, dorsal luminescent images with an exposure time of 1 s are acquired sequentially at a rate of one image per min until 20 min after D-luciferin injection. Data acquisition is continued until 40 min postinjection on days 3 or 5 and until 25 min on day 7, because of the prolonged time course of light emission. Binning is 4 and the field of view is 15 cm. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 473.7ºC at 760mmHg |
|---|---|
| Molecular Formula | C11H7N2NaO3S2 |
| Molecular Weight | 302.305 |
| Flash Point | 240.3ºC |
| Exact Mass | 301.979584 |
| PSA | 139.15000 |
| LogP | 0.04940 |
| Vapour Pressure | 2.78E-10mmHg at 25°C |
| InChIKey | LILQLBIQROYWIA-OGFXRTJISA-M |
| SMILES | O=C([O-])C1CSC(c2nc3ccc(O)cc3s2)=N1.[Na+] |
| Storage condition | −20°C |
| Water Solubility | H2O: soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934999090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| D-Luciferin sodium salt, 99% |
| 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, sodium salt, (4S)- (1:1) |
| Sodium (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate |
| MFCD00044938 |
| D-Luciferinsodiumsaltmonohydrate |
| Sodium (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylate |
| D-LUCIFERIN SODIUM SALT |
| D-Luciferin (sodium salt) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of D-Luciferin sodium salt monohydrate? |
| A: CAS number of D-Luciferin sodium salt monohydrate is 103404-75-7. |
| Q: What are the uses of D-Luciferin sodium salt monohydrate? |
| A: Main uses of D-Luciferin sodium salt monohydrate: D-Luciferin sodium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects. |
| Q: What are the storage conditions for D-Luciferin sodium salt monohydrate? |
| A: Storage conditions for D-Luciferin sodium salt monohydrate: −20°C. |
| Q: What is the boiling point of D-Luciferin sodium salt monohydrate? |
| A: Boiling point of D-Luciferin sodium salt monohydrate is 473.7ºC at 760mmHg. |
| Q: What is the English name of D-Luciferin sodium salt monohydrate? |
| A: The English name of D-Luciferin sodium salt monohydrate is D-Luciferin sodium salt monohydrate. |
| Q: What is the molecular weight of D-Luciferin sodium salt monohydrate? |
| A: Molecular weight of D-Luciferin sodium salt monohydrate is 302.305. |
| Q: What is the SMILES notation of D-Luciferin sodium salt monohydrate? |
| A: SMILES notation of D-Luciferin sodium salt monohydrate is O=C([O-])C1CSC(c2nc3ccc(O)cc3s2)=N1.[Na+]. |
| Q: What is the InChIKey of D-Luciferin sodium salt monohydrate? |
| A: InChIKey of D-Luciferin sodium salt monohydrate is LILQLBIQROYWIA-OGFXRTJISA-M. |
| Q: How is the water solubility of D-Luciferin sodium salt monohydrate? |
| A: Water solubility of D-Luciferin sodium salt monohydrate: H2O: soluble. |
| Q: What English synonyms does D-Luciferin sodium salt monohydrate have? |
| A: English synonyms of D-Luciferin sodium salt monohydrate: D-Luciferin sodium salt, 99%, 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, sodium salt, (4S)- (1:1), Sodium (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate, MFCD00044938, D-Luciferinsodiumsaltmonohydrate, Sodium (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylate, D-LUCIFERIN SODIUM SALT, D-Luciferin (sodium salt). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |