3-APPA(CGP 27492)(mM/ml)
Modify Date: 2025-08-25 21:49:42
3-APPA(CGP 27492)(mM/ml) structure
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Common Name | 3-APPA(CGP 27492)(mM/ml) | ||
|---|---|---|---|---|
| CAS Number | 103680-47-3 | Molecular Weight | 123.09 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C3H10NO2P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 3-APPA(CGP 27492)(mM/ml)3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of GABA, is a GABAB receptor agonist[1]. |
| Name | 3-aminopropyl-hydroxy-oxophosphanium |
|---|---|
| Synonym | More Synonyms |
| Description | 3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of GABA, is a GABAB receptor agonist[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84 + 0.23 μM), but does not produce an initial contraction[2]. |
| In Vivo | 3-Aminopropylphosphinic acid (5 mg/kg; iv) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3]. Animal Model: guinea pigs[3] Dosage: 5 mg/kg Administration: IV Result: Blocked the inhibitory effects of GABA against vagal broncho-spasm. |
| References |
| Molecular Formula | C3H10NO2P |
|---|---|
| Molecular Weight | 123.09 |
| Exact Mass | 122.03700 |
| PSA | 95.92000 |
| Vapour Pressure | 0.001mmHg at 25°C |
|
~41%
3-APPA(CGP 2749... CAS#:103680-47-3 |
| Literature: Queffelec, Clemence; Ribiere, Patrice; Montchamp, Jean-Luc Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 8987 - 8991 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| 3-Aminopropanephosphinic acid |
| 3-amnopropylphosphonous acid |
| 3-Aminopropylphosphonous acid |
| Cgp 27 492 |