MR2938
Modify Date: 2024-01-14 10:27:29
MR2938 structure
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Common Name | MR2938 | ||
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| CAS Number | 1044870-65-6 | Molecular Weight | 380.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H24N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MR2938MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1]. |
| Name | MR2938 |
|---|
| Description | MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1]. |
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| Related Catalog | |
| Target |
AChE:5.04 ± 0.7 μM (IC50) BChE:>20 μM (IC50) NF-κB IL-1β IL-6 NLRP3 JNK |
| In Vitro | MR2938 (0-10 μM, 24 h) 在 1.25 μM 时降低促炎细胞因子 IL-1β、TNF-α、IL-6 和 CCL2 的 mRNA 水平[1]。 MR2938 (10 μM, 24 h) 阻断 LPS 诱导的 BV-2 细胞中的 NF-κB 信号通路[1]。 MR2938 (20 μM) 对 AChE 和 BChE 具有抑制活性，抑制率分别为 91.8 ± 2.68% 和 38.7 ± 11.7%[1]。 MR2938 (0-10 μM) 对 BV2 细胞系的细胞活力影响很小[1]。 RT-PCR[1] Cell Line: BV-2 cells Concentration: 0, 1.25, 2.5, 5, and 10 μM Incubation Time: 24 h Result: Dramatically and dose dependently reduced the mRNA levels of inflammatory factors stimulated by LPS (1 μg/mL). Compared with TNF-α, the inhibitory effect of MR2938 on IL-1β, IL-6 and CCL2 was much potent. Western Blot Analysis[1] Cell Line: BV-2 cells Concentration: 10 μM Incubation Time: 24 h Result: Suppressed the expression level of p65 protein, and reduced the p-p65 level. Reduced NLRP3 expression obviously. Reduced the phosphorylation level of JNK induced by LPS stimulation, while the level of JNK protein was hardly changed. |
| References |
| Molecular Formula | C21H24N4O3 |
|---|---|
| Molecular Weight | 380.44 |