Barnidipine

Modify Date: 2025-08-21 11:07:01

Barnidipine structure	Common Name	Barnidipine
	CAS Number	104713-75-9	Molecular Weight	491.536
	Density	1.3±0.1 g/cm3	Boiling Point	614.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₉N₃O₆	Melting Point	137-139°
	MSDS	N/A	Flash Point	325.4±31.5 °C

Use of Barnidipine

Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1].Barnidipine (Mepirodipine) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].

Name	(+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Synonym	More Synonyms

Description	Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1].Barnidipine (Mepirodipine) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	Ki: 0.21 nmol/l ([3H] initrendipine)[1]
References	[1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8 [2]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.

Density	1.3±0.1 g/cm3
Boiling Point	614.5±55.0 °C at 760 mmHg
Melting Point	137-139°
Molecular Formula	C₂₇H₂₉N₃O₆
Molecular Weight	491.536
Flash Point	325.4±31.5 °C
Exact Mass	491.205627
PSA	113.69000
LogP	4.36
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.628
InChIKey	VXMOONUMYLCFJD-DHLKQENFSA-N
SMILES	COC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1
Storage condition	-20°C

Precursor 10
CAS#:101469-91-4 N-Benzyl-(3S)-h... CAS#:100-46-9 Benzylamine CAS#:775-15-5 1-Benzyl-3-pyrr... CAS#:71863-54-2 1-benzyl-3-acet...
CAS#:99-61-6 3-Nitrobenzaldehyde CAS#:101385-90-4 (3S)-1-Benzyl-3... CAS#:101930-01-2 BUTANOIC ACID,3... CAS#:14205-39-1 Methyl 3-aminoc...
CAS#:101930-02-3 3,5-Pyridinedic... CAS#:71863-55-3 barnidipine
DownStream 0

Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291800

Name: Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291792

Name: Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas...
Source: ChEMBL
Target: Prothrombin
External Id: CHEMBL5291794

Name: Choleostatic liver toxicity, either proven histopathologically or where the ratio of ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137727

Name: Severe hepatitis, defined as possibly life-threatening liver failure or through clini...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137728

Name: Chronic liver disease either proven histopathologically, or through a chonic elevatio...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137729

Name: Cirrhosis, proven histopathologically. Value is number of references indexed. [column...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137730

Name: Granulomatous liver disease, proven histopathologically. Value is number of reference...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3137731

Name: Binding affinity towards human DRD1 in an in vitro assay with cellular components (NI...
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL5291779

Name: Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive dise...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137732

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(+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Barnidipine

Hypoca

(3S)-1-Benzyl-3-pyrrolidinyl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

(3S)-1-Benzylpyrrolidin-3-yl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

mepirodipine

(4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester

(4S)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester

(S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

[S-(R*,R*)]-1,4-Dihydro-2,6-di methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 1-(Phenylmethyl)-3-pyrrolidinyl Ester

(3S)-1-benzyl-3-pyrrolidinyl methyl (4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Barnidipine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-3-((S)-1-BENZYLPYRROLIDIN-3-YL) 5-METHYL 2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Barnidipine

Use of Barnidipine

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.