β-ketoacyl-[acyl-carrier-protein] synthase III

Modify Date: 2024-01-15 07:00:49

β-ketoacyl-[acyl-carrier-protein] synthase III Structure
β-ketoacyl-[acyl-carrier-protein] synthase III structure
Common Name β-ketoacyl-[acyl-carrier-protein] synthase III
CAS Number 1048646-78-1 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of β-ketoacyl-[acyl-carrier-protein] synthase III


Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41 (β-ketoacyl-ACP synthase I) and EC 2.3.1.179 (β-ketoacyl-ACP synthase II), this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer. In addition to the above reaction, the enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent. The enzyme is responsible for initiating both straight- and branched-chain fatty-acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism. For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4-C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA. Reaction: acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2

 Names

Name β-ketoacyl-[acyl-carrier-protein] synthase III
Synonym More Synonyms

  Biological Activity

Description Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41 (β-ketoacyl-ACP synthase I) and EC 2.3.1.179 (β-ketoacyl-ACP synthase II), this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer. In addition to the above reaction, the enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent. The enzyme is responsible for initiating both straight- and branched-chain fatty-acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism. For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4-C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA. Reaction: acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2

 Chemical & Physical Properties

No Any Chemical & Physical Properties

 Synonyms

EC 2.3.1.180
3-oxoacyl:ACP synthase III
3-ketoacyl-acyl carrier protein synthase III
KASIII
KAS III
FabH
β-ketoacyl-acyl carrier protein synthase III
β-ketoacyl-ACP synthase III
β-ketoacyl (acyl carrier protein) synthase III
acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase