1048646-78-1
1048646-78-1 structure
- Name: β-ketoacyl-[acyl-carrier-protein] synthase III
- Chemical Name: β-ketoacyl-[acyl-carrier-protein] synthase III
- CAS Number: 1048646-78-1
- Molecular Formula:
- Molecular Weight:
- Create Date: 2020-04-10 13:04:32
- Modify Date: 2024-01-15 07:00:49
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Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41 (β-ketoacyl-ACP synthase I) and EC 2.3.1.179 (β-ketoacyl-ACP synthase II), this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer. In addition to the above reaction, the enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent. The enzyme is responsible for initiating both straight- and branched-chain fatty-acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism. For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4-C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA. Reaction: acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2
| Name | β-ketoacyl-[acyl-carrier-protein] synthase III |
|---|---|
| Synonyms |
EC 2.3.1.180
3-oxoacyl:ACP synthase III 3-ketoacyl-acyl carrier protein synthase III KASIII KAS III FabH β-ketoacyl-acyl carrier protein synthase III β-ketoacyl-ACP synthase III β-ketoacyl (acyl carrier protein) synthase III acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase |
| Description | Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41 (β-ketoacyl-ACP synthase I) and EC 2.3.1.179 (β-ketoacyl-ACP synthase II), this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer. In addition to the above reaction, the enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent. The enzyme is responsible for initiating both straight- and branched-chain fatty-acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism. For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4-C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA. Reaction: acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 |
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| No Any Chemical & Physical Properties |