Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride
Modify Date: 2024-01-02 21:24:15
![Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride Structure](https://www.chemsrc.com/caspic/411/1049741-81-2.png)
Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride structure
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Common Name | Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1049741-81-2 | Molecular Weight | 306.78700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H19ClN2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochlorideCiproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders. |
| Name | Ciproxifan hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Molecular Formula | C16H19ClN2O2 |
|---|---|
| Molecular Weight | 306.78700 |
| Exact Mass | 306.11400 |
| PSA | 54.98000 |
| LogP | 3.81600 |
| Storage condition | 2-8°C |
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Ciproxifan differentially modifies cognitive impairment evoked by chronic stress and chronic corticosterone administration in rats.
Behav. Brain Res. 283 , 145-53, (2015) Despite the development of neuroscience and spectacular discoveries, the clear functions and the role of histamine are still not fully understood, especially in the context of the negative impact of p... |
| cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone,hydrochloride |