Betazole

Modify Date: 2024-01-02 18:11:06

Betazole Structure
Betazole structure
Common Name Betazole
CAS Number 105-20-4 Molecular Weight 111.14500
Density 1.14g/cm3 Boiling Point 284.1ºC at 760mmHg
Molecular Formula C5H9N3 Melting Point 25°C
MSDS N/A Flash Point 150.3ºC

 Use of Betazole


Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].

 Names

Name betazole
Synonym More Synonyms

 Betazole Biological Activity

Description Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].
Related Catalog
Target

H2 Receptor

In Vitro Betazole (Ametazole) is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole induces gastric inhibitory polypeptide (GIP) secretion[1].
References

[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521.

[2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382.

[3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.

 Chemical & Physical Properties

Density 1.14g/cm3
Boiling Point 284.1ºC at 760mmHg
Melting Point 25°C
Molecular Formula C5H9N3
Molecular Weight 111.14500
Flash Point 150.3ºC
Exact Mass 111.08000
PSA 54.70000
LogP 0.61120
Vapour Pressure 0.00303mmHg at 25°C
Index of Refraction 1.567

 Safety Information

HS Code 2933199090

 Synthetic Route

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Betazole Structure

Betazole

CAS#:105-20-4

Literature: Jones; Mann Journal of the American Chemical Society, 1953 , vol. 75, p. 4048,4050

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Betazole Structure

Betazole

CAS#:105-20-4

Literature: Jones et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 4000

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933199090
Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-(1(2)H-Pyrazol-3-yl)-aethylamin
3-(2-aminoethyl)pyrazole
Ametazole
3-(2-Aminoethyl)-1H-pyrazole
3-(2-Aminoethyl)pyrazol
2-(1H-pyrazol-5-yl)ethanamine(SALTDATA: FREE)
2-(1(2)H-pyrazol-3-yl)-ethylamine
EINECS 203-278-3