Z164597606

Modify Date: 2025-08-25 20:09:35

Z164597606 Structure
Z164597606 structure
 Common Name Z164597606
CAS Number 1050587-57-9 Molecular Weight 365.38
Density N/A Boiling Point N/A
Molecular Formula C20H19N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Z164597606


Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2].

 Names

Name Z164597606

 Z164597606 Biological Activity

Description Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2].
Related Catalog
Target

eqBCHE:1.3 μM (IC50)

hBCHE:1.7 μM (IC50)

In Vitro Z164597606 (10 μM) potently inhibits BChE activity, with no more than 30% inhibitory against ACHE[1]. Z164597606 (0.5-20 μM) may bind to catalytic “anionic” site (CAS) when interacting with BChE (determined by Lineweaver-Burk reciprocal plots)[1]. Z164597606 (10 and 50 μM) shows no toxicity on neuronal cell line SH-SY5Y[1].
References

[1]. Xin Lu, et al. Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation. Bioorg Chem. 2019 Apr;85:117-127.

[2]. Xin Lu, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729.

 Chemical & Physical Properties

Molecular Formula C20H19N3O4
Molecular Weight 365.38
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here
Related Compounds: More...
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-(2-(cyclohex-1-en-1-yl)ethyl)acetamide
1326882-49-8
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-cyclopentylacetamide
1326890-65-6
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-methyl-N-phenylacetamide
1326807-27-5
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-phenylacetamide
1326890-70-3
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-(4-fluorobenzyl)acetamide
1326930-12-4
N-(3-acetylphenyl)-2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)acetamide
1326882-58-9
2-{5-[3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl]-2-oxopyridin-1(2H)-yl}-N-(propan-2-yl)acetamide
1326868-46-5
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-(3-phenylpropyl)acetamide
1326871-66-2
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-(4-methoxybenzyl)acetamide
1326855-32-6
2-(5-(3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl)-2-oxopyridin-1(2H)-yl)-N-(3-methoxybenzyl)acetamide
1326890-74-7
Chemsrc provides Z164597606(CAS#:1050587-57-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Z164597606 are included as well.>> amp version: Z164597606

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved