Lefamulin(BC-3781)
Modify Date: 2024-01-09 16:56:14
Lefamulin(BC-3781) structure
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Common Name | Lefamulin(BC-3781) | ||
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| CAS Number | 1061337-51-6 | Molecular Weight | 507.72600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H45NO5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lefamulin(BC-3781)Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia[1]. |
| Name | bc-3781 |
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| Synonym | More Synonyms |
| Description | Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia[1]. |
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| Related Catalog | |
| In Vitro | Lefamulin (0-1 mg/L) shows inhibitory activity against C. trachomatis, N. gonorrhoeae, and M. genitalium[2]. Lefamulin shows potent activity against all M. pneumoniae strains with MIC values of ≤0.008 μg/mL[3]. Cell Viability Assay[1] Cell Line: C. trachomatis, N. gonorrhoeae, and M. genitalium Concentration: 0-1 mg/L Incubation Time: Result: Inhibited bacterial activity with MIC50s of 0.02 mg/L, 0.063 mg/L and 0.12 mg/L respectively. |
| In Vivo | Lefamulin (10-140 mg/kg, s.c.) shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model[4]. Lefamulin (1.25-160 mg/kg, s.c.) shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice[5]. Animal Model: LPS-induced lung neutrophilia mouse model[4] Dosage: 10-140 mg/kg Administration: Subcutaneous injection (s.c.) Result: Reduced BALF neutrophil cell counts. Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue. |
| Molecular Formula | C28H45NO5S |
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| Molecular Weight | 507.72600 |
| Exact Mass | 507.30200 |
| PSA | 135.15000 |
| LogP | 4.56710 |
| 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin |