CXL017
Modify Date: 2025-08-25 14:19:03
CXL017 structure
|
Common Name | CXL017 | ||
|---|---|---|---|---|
| CAS Number | 1063714-11-3 | Molecular Weight | 441.474 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 571.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H27NO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 188.6±26.4 °C | |
Use of CXL017CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM; selectively suppresses the growth of tumors derived from the MDR cancer cell line, HL60/MX2, in vivo; significantly downregulates Mcl-1 and Bax and up-regulates Noxa, Bim, Bcl-XL, SERCA2, and SERCA3 proteins, along with a reduction in endoplasmic reticulum (ER) calcium content in HL60/MX2 cells; elicits its cytotoxic effect, in part, through inhibition of the SERCA. |
| Name | Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
|---|---|
| Synonym | More Synonyms |
| Description | CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM; selectively suppresses the growth of tumors derived from the MDR cancer cell line, HL60/MX2, in vivo; significantly downregulates Mcl-1 and Bax and up-regulates Noxa, Bim, Bcl-XL, SERCA2, and SERCA3 proteins, along with a reduction in endoplasmic reticulum (ER) calcium content in HL60/MX2 cells; elicits its cytotoxic effect, in part, through inhibition of the SERCA. |
|---|---|
| References | References 1. Das SG, et al. ACS Chem Biol. 2013 Feb 15;8(2):327-35. 2. Aridoss G, et al. J Med Chem. 2012 Jun 14;55(11):5566-81. 3. Hermanson DL, et al. Mol Pharmacol. 2013 Aug;84(2):236-43. 4. Bleeker NP, et al. Mol Pharm. 2013 Nov 4;10(11):4358-66. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 571.4±50.0 °C at 760 mmHg |
| Molecular Formula | C24H27NO7 |
| Molecular Weight | 441.474 |
| Flash Point | 188.6±26.4 °C |
| Exact Mass | 441.178741 |
| LogP | 3.79 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.553 |
| Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
| 4H-1-Benzopyran-4-acetic acid, 2-amino-6-(3,5-dimethoxyphenyl)-3-(ethoxycarbonyl)-, ethyl ester |