ASB 14780
Modify Date: 2025-09-12 12:12:46
ASB 14780 structure
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Common Name | ASB 14780 | ||
|---|---|---|---|---|
| CAS Number | 1069046-00-9 | Molecular Weight | 582.686 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H27NO3·C4H11NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ASB 14780ASB 14780 (ASB14780, ASB-14780) is a potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM; displays excellen selectivity over other known secreted phospholipase A2s (sPLA2s), such as sPLA2-IA, sPLA2-IIA, sPLA2-III, and sPLA2-IB; markedly ameliorates liver injury and hepatic fibrosis, attenuates the CCl4-induced expression of α-SMA protein and the mRNA expression of collagen 1a2, α-SMA, and TGF-β1 in the liver, and inhibits the expression of monocyte/macrophage markers, CD11b and MCP-1 in vivo, while preventing the recruitment of monocytes/macrophages to the liver. |
| Name | ASB14780 |
|---|---|
| Synonym | More Synonyms |
| Description | ASB 14780 (ASB14780, ASB-14780) is a potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM; displays excellen selectivity over other known secreted phospholipase A2s (sPLA2s), such as sPLA2-IA, sPLA2-IIA, sPLA2-III, and sPLA2-IB; markedly ameliorates liver injury and hepatic fibrosis, attenuates the CCl4-induced expression of α-SMA protein and the mRNA expression of collagen 1a2, α-SMA, and TGF-β1 in the liver, and inhibits the expression of monocyte/macrophage markers, CD11b and MCP-1 in vivo, while preventing the recruitment of monocytes/macrophages to the liver. |
|---|---|
| References | References 1. Tomoo T, et al. J Med Chem. 2014 Sep 11;57(17):7244-62. 2. Kanai S, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):604-14. View Related Products by Target Phospholipase |
| Molecular Formula | C31H27NO3·C4H11NO3 |
|---|---|
| Molecular Weight | 582.686 |
| Exact Mass | 582.273010 |
| InChIKey | AVSDLGNMCGTBHT-UHFFFAOYSA-N |
| SMILES | O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(Oc2ccccc2)cc1 |
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Name: Inhibition of porcine pancreas sPLA2-IB assessed as suppression of [14C]arachidonic a...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3362182
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Name: Inhibition of crotalus venom sPLA2-IIA assessed as suppression of [14C]arachidonic ac...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3362180
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Name: Inhibition of bee venom sPLA2-III assessed as suppression of [14C]arachidonic acid re...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3362181
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Name: Oral bioavailability in beagle dog at 10 mg/kg
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL3362186
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Name: Oral bioavailability in cynomolgus monkey at 10 mg/kg
Source: ChEMBL
Target: Macaca fascicularis
External Id: CHEMBL3362187
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Name: Oral bioavailability in C57BL/6 mouse at 10 mg/kg
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3362185
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Name: AUC in cynomolgus monkey at 10 mg/kg, po
Source: ChEMBL
Target: Macaca fascicularis
External Id: CHEMBL3362190
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Name: AUC in C57BL/6 mouse at 10 mg/kg, po
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3362188
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|
Name: AUC in beagle dog at 10 mg/kg, po
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL3362189
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|
Name: Antiasthmatic activity in ovalbumin-induced asthma model in Hartley guinea pig assess...
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL3362194
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| ASB14780 |
| 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol |
| 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol |
| 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) |
| 1H-Indole-5-propanoic acid, 1-(4-phenoxyphenyl)-3-(2-phenylethyl)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) |