Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

Modify Date: 2026-07-15 12:42:45

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate structure
 Common Name Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
CAS Number 106939-34-8 Molecular Weight 309.265
Density 1.4±0.1 g/cm3 Boiling Point 442.2±45.0 °C at 760 mmHg
Molecular Formula C15H13F2NO4 Melting Point 258-260ºC
MSDS N/A Flash Point 221.2±28.7 °C

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.4±0.1 g/cm3
Boiling Point 442.2±45.0 °C at 760 mmHg
Melting Point 258-260ºC
Molecular Formula C15H13F2NO4
Molecular Weight 309.265
Flash Point 221.2±28.7 °C
Exact Mass 309.081268
PSA 57.53000
LogP 1.28
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.582
InChIKey TZSXJUSNOOBBOP-ZETCQYMHSA-N
SMILES CCOC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)OCC2C

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code 2934999090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

(3S)-(+)-7,8-Difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine structure

(3S)-(+)-7,8-Di...

CAS#:106939-42-8

Diethyl ethoxymethylenemalonate structure

Diethyl ethoxym...

CAS#:87-13-8

~68%

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure

Ethyl (S)-9,10-...

CAS#:106939-34-8

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Literature: EP368410 A3, ;
ethyl (S,Z)-3-((1-hydroxypropan-2-yl)amino)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate structure

ethyl (S,Z)-3-(...

CAS#:110548-02-2

~%

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure

Ethyl (S)-9,10-...

CAS#:106939-34-8

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Literature: WO2006/48889 A1, ; Page/Page column 16-17 ;
(-)-ethyl 9,10-difluoro-2,3-dihydro-3-iodomethyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate structure

(-)-ethyl 9,10-...

CAS#:113472-54-1

~74%

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure

Ethyl (S)-9,10-...

CAS#:106939-34-8

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Literature: Chemical and pharmaceutical bulletin, , vol. 35, # 5 p. 1896 - 1902
N/A structure

N/A

CAS#:91040-39-0

~%

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure

Ethyl (S)-9,10-...

CAS#:106939-34-8

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Literature: Chemical and pharmaceutical bulletin, , vol. 35, # 5 p. 1896 - 1902
N/A structure

N/A

CAS#:100986-87-6

~%

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure

Ethyl (S)-9,10-...

CAS#:106939-34-8

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Literature: Chemical and pharmaceutical bulletin, , vol. 35, # 5 p. 1896 - 1902
N/A structure

N/A

CAS#:100986-91-2

~%

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure

Ethyl (S)-9,10-...

CAS#:106939-34-8

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Literature: Chemical and pharmaceutical bulletin, , vol. 35, # 5 p. 1896 - 1902
(S)-ethyl 3-(((3,5-dinitrobenzoyl)oxy)methyl)-9,10-difluoro-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate structure

(S)-ethyl 3-(((...

CAS#:106939-31-5

~%

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Structure

Ethyl (S)-9,10-...

CAS#:106939-34-8

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Literature: Chemical and pharmaceutical bulletin, , vol. 35, # 5 p. 1896 - 1902

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  5

DownStream  1

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Bioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antibacterial activity against Staphylococcus aureus assessed growth inhibition by mi...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL5529162
Name: Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed g...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL5529161
Name: Antibacterial activity against Acinetobacter baumannii assessed growth inhibition by ...
Source: ChEMBL
Target: Acinetobacter baumannii
External Id: CHEMBL5529171
Name: Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed growth inhi...
Source: ChEMBL
Target: Pseudomonas aeruginosa
External Id: CHEMBL5529170
Name: Antibacterial activity against Pseudomonas aeruginosa assessed growth inhibition by m...
Source: ChEMBL
Target: Pseudomonas aeruginosa
External Id: CHEMBL5529169
Name: Antibacterial activity against Escherichia coli ATCC 25922 assessed growth inhibition...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL5529168
Name: Antibacterial activity against Escherichia coli assessed growth inhibition by micro b...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL5529167
Name: Antibacterial activity against Klebsiella pneumonia assessed growth inhibition by mic...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL5529166
Name: Antibacterial activity against Enterococcus faecalis assessed growth inhibition by mi...
Source: ChEMBL
Target: Enterococcus faecalis
External Id: CHEMBL5529165
Name: Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed growth inhib...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL5529164
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester
Levofiexacin acid ester
T666 1A M BN EO KVT&&J C1 Gf HF LVO2 &&S Form
(-)-ethyl 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylate
ethyl (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate
Ethyl (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
Levofloxacin cyclized ester
(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
(S)-ethyl-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido-[1,2,3-de]-1,4-benzoxazine-6-carboxylate
Levofloxacin Ethyl Ester

  | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: Boiling point of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is 442.2±45.0 °C at 760 mmHg.
Q: What is the molecular formula of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: Molecular formula of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is C15H13F2NO4.
Q: What is the melting point of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: Melting point of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is 258-260ºC.
Q: What is the InChIKey of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: InChIKey of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is TZSXJUSNOOBBOP-ZETCQYMHSA-N.
Q: What is the English name of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: The English name of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate.
Q: What are the upstream materials of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: Related upstream materials(CAS) of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate: 106939-42-8;87-13-8;110548-02-2;113472-54-1;106939-31-5.
Q: What is the polar surface area (PSA) of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: Polar surface area (PSA) of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is 57.53000.
Q: What are the downstream products of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: Related downstream products(CAS) of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate: 100986-89-8.
Q: What is the SMILES notation of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: SMILES notation of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is CCOC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)OCC2C.
Q: What is the CAS number of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate?
A: CAS number of ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate is 106939-34-8.

 factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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Chemsrc provides CAS#:106939-34-8 MSDS, density, melting point, boiling point, structure, etc. Its name is Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate>> amp version: Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

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