2,5-Biphenyldiol

Modify Date: 2025-08-21 23:18:02

2,5-Biphenyldiol Structure
2,5-Biphenyldiol structure
 Common Name 2,5-Biphenyldiol
CAS Number 1079-21-6 Molecular Weight 186.207
Density 1.2±0.1 g/cm3 Boiling Point 383.0±30.0 °C at 760 mmHg
Molecular Formula C12H10O2 Melting Point 98-100 °C(lit.)
MSDS Chinese USA Flash Point 192.3±19.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 2,5-Biphenyldiol


TFIIH Modulator-12 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.

 Names

Name Phenylhydroquinone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 383.0±30.0 °C at 760 mmHg
Melting Point 98-100 °C(lit.)
Molecular Formula C12H10O2
Molecular Weight 186.207
Flash Point 192.3±19.2 °C
Exact Mass 186.068085
PSA 40.46000
LogP 2.09
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.640
InChIKey XCZKKZXWDBOGPA-UHFFFAOYSA-N
SMILES Oc1ccc(O)c(-c2ccccc2)c1

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DV4550000
CHEMICAL NAME :
2,5-Biphenyldiol
CAS REGISTRY NUMBER :
1079-21-6
BEILSTEIN REFERENCE NO. :
1949429
LAST UPDATED :
199806
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C12-H10-O2
MOLECULAR WEIGHT :
186.22
WISWESSER LINE NOTATION :
QR DQ BR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1010 mg/m3/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Endocrine - changes in spleen weight Endocrine - changes in thymus weight
TYPE OF TEST :
DNA adduct

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,1,1991

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DV4550000
HS Code 2907299090

 Synthetic Route

 Customs

HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

 Articles27

More Articles
Cytotoxic effects of phenyl-hydroquinone and some hydroquinones on isolated rat hepatocytes.

Biochem. Pharmacol. 44(6) , 1059-65, (1992)

The cytotoxic effects of phenyl-hydroquinone (PHQ) and some other hydroquinones on freshly isolated rat hepatocytes were investigated. Addition of PHQ (0.5 or 0.75 mM) to the hepatocytes elicited dose...

Tuning surface hydrophilicity/hydrophobicity of hydrocarbon proton exchange membranes (PEMs).

J. Colloid. Interface Sci. 466 , 168-77, (2016)

The effect of annealing on the surface hydrophilicity of various representative classes of hydrocarbon-based proton exchange membranes (PEMs) is investigated. In all cases, a more hydrophilic membrane...

Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis.

Carcinogenesis 12(1) , 145-9, (1991)

o-Phenylphenol (OPP) and its sodium salt sodium ortho-phenylphenate (NaOPP) are broad spectrum fungicides and antibacterial agents. Both are urinary bladder and renal carcinogens in the Fischer 344 ra...

 Synonyms

2,5-Dihydroxy-biphenyl
2,5-Biphenyldiol
EINECS 214-091-1
[1,1'-Biphenyl]-2,5-diol
4-hydroxy-2-phenylphenol
Biphenyl-2,5-diol
2-phenylhydroquinone
PHENYLHYDROQUINONE
MFCD00002342
2,5-Dihydroxybiphenyl
2,5-Dihydroxybiphenyl,2,5-Biphenyldiol
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