Roxindole hydrochloride

Modify Date: 2024-01-09 17:56:08

Roxindole hydrochloride structure	Common Name	Roxindole hydrochloride
	CAS Number	108050-82-4	Molecular Weight	382.92600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₇ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Roxindole hydrochloride

Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3].

Name	Roxindole hydrochloride
Synonym	More Synonyms

Description	Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vivo	Roxindole hydrochloride inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[1]. Roxindole hydrochloride (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3].
References	[1]. Bartoszyk GD, Harting J, Minck KO. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48. [2]. Wetzel H, et al. Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms. Am J Psychiatry. 1994;151(10):1499-1502. [3]. Maj J, et al. Roxindole, a dopamine autoreceptor agonist with a potential antidepressant activity. II. Effects on the 5-hydroxytryptamine system. Pharmacopsychiatry. 1997;30(2):55-61. [4]. Prehn JH, et al. Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain Res. 1993;630(1-2):10-20.

Molecular Formula	C₂₃H₂₇ClN₂O
Molecular Weight	382.92600
Exact Mass	382.18100
PSA	39.26000
LogP	5.72540

5-hydroxy-3-[4-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole hydrochloride

3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-1H-indol-5-ol

hydrochloride

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Roxindole hydrochloride
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
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DC Chemicals Limited
China
Product Name: Roxindole hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Roxindole hydrochloride

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