AS-35
Modify Date: 2024-01-13 17:11:39
AS-35 structure
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Common Name | AS-35 | ||
|---|---|---|---|---|
| CAS Number | 108427-72-1 | Molecular Weight | 420.42100 | |
| Density | 1.46g/cm3 | Boiling Point | 678.8ºC at 760mmHg | |
| Molecular Formula | C21H20N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 364.4ºC | |
Use of AS-35AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities. |
| Name | 9-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]-3-(2H-tetrazol-5-yl)pyrido[1,2-a]pyrimidin-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities. |
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| Related Catalog | |
| Target |
LTE4:3 nM (IC50, In isolated guinea pig ileum) LTD4:4 nM (IC50, In isolated guinea pig ileum) LTC4:8 nM (IC50, In isolated guinea pig ileum) |
| In Vitro | In isolated guinea pig preparations, AS-35 antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively. In the trachea, the agent also antagonizes LTD4 and LTE4-induced con tractions with IC50 values of 10 nM and 20 nM, respectively. However, AS-35 does not antagonize LTC4-induced tracheal contraction in the presence of L-serine borate[1]. |
| In Vivo | AS-35 (0.0375 to 0.3 mg/kg, i.v.) dose-dependently antagonizes bronchoconstriction induced by i.v.-injection of LTC4 and LTD4 in anesthetized guinea pigs, but does not inhibit histamine-induced bronchoconstriction. Oral administration of AS-35 also antagonizes LTD4 as well as antigen-induced LT-mediated bronchoconstriction. AS-35 (p.o.) inhibits LTD4-induced increase in the cutaneous vascular permeability of guinea pig[1]. |
| References |
| Density | 1.46g/cm3 |
|---|---|
| Boiling Point | 678.8ºC at 760mmHg |
| Molecular Formula | C21H20N6O4 |
| Molecular Weight | 420.42100 |
| Flash Point | 364.4ºC |
| Exact Mass | 420.15500 |
| PSA | 135.36000 |
| LogP | 2.31430 |
| Vapour Pressure | 4.74E-19mmHg at 25°C |
| Index of Refraction | 1.707 |
| Storage condition | 2-8℃ |
|
~98%
AS-35 CAS#:108427-72-1 |
| Literature: Tokyo Tanabe Co. Ltd. Patent: US4816459 A1, 1989 ; |
|
~65%
AS-35 CAS#:108427-72-1 |
| Literature: Tokyo Tanabe Co. Ltd. Patent: US4816459 A1, 1989 ; |
![9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy)methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt structure](https://image.chemsrc.com/caspic/359/108427-83-4.png)
![9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy)methyl]-3-cyano-4H-pyrido[1,2-a]pyrimidin-4-one structure](https://image.chemsrc.com/caspic/141/108428-04-2.png)
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| as-35 |