AZP-531
Modify Date: 2024-01-06 00:05:36
AZP-531 structure
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Common Name | AZP-531 | ||
|---|---|---|---|---|
| CAS Number | 1088543-62-7 | Molecular Weight | 962.021 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C40H63N15O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZP-531AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. |
| Name | AZP-531 |
|---|---|
| Synonym | More Synonyms |
| Description | AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. |
|---|---|
| Related Catalog | |
| In Vitro | AZP-531 exerts survival effects on pancreatic b-cells and human pancreatic islets which is comparable to that of UAG, the parent molecule. AZP-531 is very stable in human plasma in vitro. No degradation is observed after 1 day of incubation at 37°C[1]. |
| In Vivo | The highest concentration of this peptide is 4350 ng/mL, and the majority of samples are above the limit of quantification (1 ng/mL)[1]. AZP-531 infusion prevents the increase in body weight caused by high-fat diet in mice. AZP-531 treatment prevents high-fat diet-induced proinflammatory effects, stimulates expression of mitochondrial function markers in brown adipose tissue, and prevents development of a prediabetic metabolic state. AZP-531 also prevents a high-fat diet-induced increase in acyl ghrelin levels[2]. AZP-531 is well tolerated. Single- and multiple-dose pharmokinetic variables are similar. Maximum AZP-531 concentrations are typically reached at 1 h post-dose. Observed maximum concentration and area under the curve are dose-proportional. The mean terminal half-life is 2–3 h. AZP-531 (≥15 μg/kg) significantly improves glucose concentrations, without increasing insulin levels, suggesting an insulin-sensitizing effect. AZP-531 decreases mean body weight by 2.6 kg (vs 0.8 kg for placebo). Glucose variables improve in all groups, including placebo, suggesting a study effect in uncontrolled patients at baseline. AZP-531 60 μg/kg reduces HbA1c by 0.4% (vs 0.2% for placebo) and body weight by 2.1 kg (vs 1.3 kg for placebo)[3]. |
| Animal Admin | Rats: AZP-531 is administered in sterile water to obtain a 1 mg/kg and 0.3 mg/kg dose in the rat through both intravenous and subcutaneous routes. Blood is collected at t=0, 2, 5, 15, 30, 60, 120, 240, 360, 480 and 1440 min post-administration for the intravenous dose route and t=0, 15, 30, 60, 120, 240, 360, 480 and 1440 min post-administration for the subcutaneous route[1]. Mice: AZP531 is prepared in saline. C57BL/6J mice are infused with saline, DAG, or AZP531 continuously for 4 weeks, and fed either normal diet (ND) or normal diet for 2 weeks followed by a high-fat diet (HFD) for 2 weeks. Peptides are infused at 4 nM/kg/h[2]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C40H63N15O13 |
| Molecular Weight | 962.021 |
| Exact Mass | 961.472961 |
| LogP | -9.96 |
| Index of Refraction | 1.707 |
| Storage condition | -20°C |
| Cyclo(L-arginyl-L-valyl-L-glutaminyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl) |
| 9VHD7J6363 |
- DC Chemicals Limited
- China
- Product Name: Livoletide
- Price: $1300.0/100mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: AZP-531
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
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Price: $144/1mg
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