β-S-ARCA

Modify Date: 2024-04-06 16:56:23

β-S-ARCA Structure
β-S-ARCA structure
Common Name β-S-ARCA
CAS Number 1093268-63-3 Molecular Weight 832.52
Density N/A Boiling Point N/A
Molecular Formula C22H31N10O17P3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of β-S-ARCA


β-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines[1].

 Names

Name β-S-ARCA

 β-S-ARCA Biological Activity

Description β-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines[1].
Related Catalog
References

[1]. Warminski M, et al. Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 Feb 19;16(2):334-343.

 Chemical & Physical Properties

Molecular Formula C22H31N10O17P3S
Molecular Weight 832.52