Pyrithioxin

Modify Date: 2024-01-02 12:15:57

Pyrithioxin Structure
Pyrithioxin structure
Common Name Pyrithioxin
CAS Number 1098-97-1 Molecular Weight 368.47100
Density 1.448 g/cm3 Boiling Point 742.8ºC at 760 mmHg
Molecular Formula C16H20N2O4S2 Melting Point 54-57 °C(lit.)
MSDS Chinese USA Flash Point >230 °F
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of Pyrithioxin


Pyrithioxin is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.

 Names

Name 5-[[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyldisulfanyl]methyl]-4-(hydroxymethyl)-2-methylpyridin-3-ol
Synonym More Synonyms

 Pyrithioxin Biological Activity

Description Pyrithioxin is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.
Related Catalog
References

[1]. Stoica E, et al. Facilitation through hyperventilation of therapeutic effect of pyrithioxin in cerebral infarct patients. Eur Neurol. 1975;13(4):285-303.

 Chemical & Physical Properties

Density 1.448 g/cm3
Boiling Point 742.8ºC at 760 mmHg
Melting Point 54-57 °C(lit.)
Molecular Formula C16H20N2O4S2
Molecular Weight 368.47100
Flash Point >230 °F
Exact Mass 368.08600
PSA 157.30000
LogP 2.57080

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT4836666
CHEMICAL NAME :
4-Pyridinemethanol, 3,3'-(dithiobis(methylene))bis(5-hydroxy-6-methyl-
CAS REGISTRY NUMBER :
1098-97-1
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H20-N2-O4-S2
MOLECULAR WEIGHT :
368.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4598079

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS UT4836666
HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles25

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[The use of encephabol in neurological practice].

Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 102(6) , 53-6, (2002)

Stability-indicating chemometric methods for the determination of pyritinol dihydrochloride.

Drug Test. Anal. 1(5) , 228-33, (2009)

Three multivariate calibration methods, including classical least square with nonzero intercept (CLS), principal component regression (PCR) and partial least square (PLS), have been used for the deter...

Pyritinol reduces nociception and oxidative stress in diabetic rats

Eur. J. Pharmacol. 590(1-3) , 170-6, (2008)

The purpose of this study was to assess the antinociceptive and antiallodynic effect of pyritinol as well as its possible mechanism of action in diabetic rats. Streptozotocin (50 mg/kg) injection caus...

 Synonyms

Epocan
Dipyridoxolyldisulfide
Pyrithioxine
MFCD00151477
Bonifen
Piritinol
Pyridoxine disulfide
Bonol
PYRITINOL
Encefabol
Pyrithioxin
EINECS 214-150-1