Granisetron

Modify Date: 2024-01-02 20:49:34

Granisetron structure	Common Name	Granisetron
	CAS Number	109889-09-0	Molecular Weight	312.41
	Density	1.3±0.1 g/cm3	Boiling Point	532.0±40.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₂₄N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	275.6±27.3 °C

Use of Granisetron

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) [1]Target: 5-HT3 receptorin vitro: In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT [1].in vivo: Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion [2]. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation [3].Clinical trial: Effect of External Heat on a Transdermal Granisetron Patch in Pharmacokinetics (PK) of Healthy Subjects. Phase 1

Name	granisetron
Synonym	More Synonyms

Description	Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) [1]Target: 5-HT3 receptorin vitro: In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT [1].in vivo: Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion [2]. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation [3].Clinical trial: Effect of External Heat on a Transdermal Granisetron Patch in Pharmacokinetics (PK) of Healthy Subjects. Phase 1
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur J Pharmacol. 1989 Jan 10;159(2):113-24. [2]. Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. Int Immunopharmacol. 2010 Sep;10(9):1010-6. [3]. Boccia RV, Gordan LN, Clark G, Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study. Support Care Cancer. 2011 Oct;19(10):1609-17.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

References

[1]. Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur J Pharmacol. 1989 Jan 10;159(2):113-24.

[2]. Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. Int Immunopharmacol. 2010 Sep;10(9):1010-6.

[3]. Boccia RV, Gordan LN, Clark G, Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study. Support Care Cancer. 2011 Oct;19(10):1609-17.

Density	1.3±0.1 g/cm3
Boiling Point	532.0±40.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₄N₄O
Molecular Weight	312.41
Flash Point	275.6±27.3 °C
PSA	50.16000
LogP	1.47
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.690
Storage condition	-20℃

HS Code	2934999090

exo-3-Amino-9-m...

CAS#:76272-41-8

1-METHYL-1H-IND...

CAS#:106649-02-9

Granisetron

CAS#:109889-09-0

Literature: Journal of Medicinal Chemistry, , vol. 33, # 7 p. 1924 - 1929

1-Methyl-3-inda...

CAS#:50890-83-0

Granisetron

CAS#:109889-09-0

Literature: Journal of Medicinal Chemistry, , vol. 33, # 7 p. 1924 - 1929

Granisetron hyd...

CAS#:107007-99-8

Granisetron

CAS#:109889-09-0

Literature: US2008/242696 A1, ; Page/Page column 3 ;

Precursor 4
CAS#:76272-41-8 exo-3-Amino-9-m... CAS#:106649-02-9 1-METHYL-1H-IND... CAS#:50890-83-0 1-Methyl-3-inda... CAS#:107007-99-8 Granisetron hyd...
DownStream 1
CAS#:107007-99-8 Granisetron hyd...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-(H)Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide

Kevatril

BIDD:GT0272

Sancuso

[3H]-Granisetron

UNII-WZG3J2MCOL

1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide

HMS2089P14

granisetron hydrochloride

1H-Indazole-3-carboxamide, 1-(methyl-d)-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Granisetron
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Granisetron
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Granisetron
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Granisetron suppliers

Price: $84/50mg

Reference only. check more Granisetron price

Granisetron

Use of Granisetron

Names

Granisetron Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms