Temocaprilat
Modify Date: 2024-01-02 18:17:16
Temocaprilat structure
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Common Name | Temocaprilat | ||
|---|---|---|---|---|
| CAS Number | 110221-53-9 | Molecular Weight | 448.556 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 743.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H24N2O5S2 | Melting Point | >230ºC (dec) | |
| MSDS | N/A | Flash Point | 403.5±32.9 °C | |
Use of TemocaprilatTemocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation[1][2][3][4]. |
| Name | Temocaprilat |
|---|---|
| Synonym | More Synonyms |
| Description | Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation[1][2][3][4]. |
|---|---|
| Related Catalog | |
| In Vitro | Temocaprilat (1、10、100 和 1000 nM；72 h) 以剂量依赖性方式缓解了高糖 (22.2 mM) 介导的人主动脉内皮细胞 (HAECs) 增殖抑制。Temocaprilat 在 HAECs 中抑制高糖诱导的氧化应激[1]。 Temocaprilat (1 µM；10 min) 在 HAECs 中增加了蛋白激酶 C (PKC) 活性[1]。 Temocaprilat (0.1 µM) 通过降低 IL-6 mRNA 的稳定性抑制 IL-1β 诱导的 IL-6 表达[4]。 |
| In Vivo | Temocaprilat (1 mg/kg/d；静脉注射；4 周) 在自发性高血压大鼠 (SHRs) 中，以时间依赖性方式显著降低了收缩压。Temocaprilat 改善了 Wistar-Kyoto (WKY) 小鼠和 SHR 小鼠的心肌纤维化及氧化应激[3]。 Animal Model: Six 10-week-old WKYs and SHRs and six 50-week-old (aging control) SHRs[3]. Dosage: 1 mg/kg/d. Administration: Intravenous injection; 4 weeks. Result: Reduced the expression levels of myocardial fibrosis, transforming growth factor-β1 (TGF-β1) mRNA and fibroblast growth factor-2 (FGF-2) mRNA in the left ventricle (LV). Weakened the expression levels of 8-isoprostane, p22phox mRNA, p47phox mRNA and gp91phox mRNA in LV. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 743.6±60.0 °C at 760 mmHg |
| Melting Point | >230ºC (dec) |
| Molecular Formula | C21H24N2O5S2 |
| Molecular Weight | 448.556 |
| Flash Point | 403.5±32.9 °C |
| Exact Mass | 448.112671 |
| PSA | 160.48000 |
| LogP | 3.51 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.665 |
| Storage condition | -20°C |
| Precursor 10 | |
|---|---|
| DownStream 0 | |
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CAS#:110221-37-9| (2S-(2a,6b(R*)))-6-((1-Carboxy-3-phenylpropyl)amino)tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid |
| [[[2S,6R]-6-[[(S)-1-Carboxy-3-phenylpropyl]amino]hexahydro-5-oxo-2-(2-thienyl)-1,4-thiazepin]-4-yl]acetic acid |
| 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- |
| (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid |
| Temocaprilat |
| (2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid |
| (2S)-2-{[(2S,6R)-4-(Carboxymethyl)-5-oxo-2-(2-thienyl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid |
| Temocapril Diacid |
| (+)-(2S,6R)-6-(((1S)-1-carboxy-3-phenylpropyl)amino)tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid |
| (2S)-2-{[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid |
| RS-5139 |