SNT-207858
Modify Date: 2024-01-11 20:20:44
SNT-207858 structure
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Common Name | SNT-207858 | ||
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| CAS Number | 1104080-42-3 | Molecular Weight | 689.543 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H45Cl4N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SNT-207858SNT-207858 is a selective and orally available melanocortin MC-4 receptor antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. SNT-207858 has an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. |
| Name | N-[(2R)-3-(2,4-Dichlorophenyl)-1-oxo-1-(4-{3-[(2R)-2-(1-pyrrolidinyl)butoxy]-2-pyridinyl}-1-piperidinyl)-2-propanyl]-1-pyrrolidinecarboximidic acid dihydrochloride |
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| Synonym | More Synonyms |
| Description | SNT-207858 is a selective and orally available melanocortin MC-4 receptor antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. SNT-207858 has an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. |
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| Related Catalog | |
| Target |
IC50: 8 nM (binding, MC-4), 5 nM (function, MC-4)[1] |
| In Vivo | Subcutaneous injection or oral treatment by gavage of SNT-207858 distinctly increase food intake in healthy mice. In mice subcutaneously implanted with C26 adenocarcinoma cells, repeated oral administration (starting the day after tumor implantation) of SNT-207858 almost completely prevents tumor induced weight loss, and diminished loss of lean body mass and fat mass[1]. |
| Animal Admin | Mice[1] Twelve weeks old male CD-1 mice are dosed by gavage with SNT207858 at 60 mg/kg. At 1, 3, and 6 hrs post-dose, mice are euthanized and blood is collected[1]. |
| References |
| Molecular Formula | C32H45Cl4N5O3 |
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| Molecular Weight | 689.543 |
| Exact Mass | 687.227661 |
| 1-Pyrrolidinecarboximidic acid, N-[(1R)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-2-[4-[3-[(2R)-2-(1-pyrrolidinyl)butoxy]-2-pyridinyl]-1-piperidinyl]ethyl]-, hydrochloride (1:2) |
| N-[(2R)-3-(2,4-Dichlorophenyl)-1-oxo-1-(4-{3-[(2R)-2-(1-pyrrolidinyl)butoxy]-2-pyridinyl}-1-piperidinyl)-2-propanyl]-1-pyrrolidinecarboximidic acid dihydrochloride |
| SNT-207858 |