CGS 20625

Modify Date: 2024-01-29 11:18:48

CGS 20625 Structure
CGS 20625 structure
Common Name CGS 20625
CAS Number 111205-55-1 Molecular Weight 309.36
Density 1.246g/cm3 Boiling Point 503.8ºC at 760mmHg
Molecular Formula C18H19N3O2 Melting Point N/A
MSDS N/A Flash Point 258.5ºC

 Use of CGS 20625


CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures[1].

 Names

Name 2-(4-methoxyphenyl)-1,6,7,8,9,10-hexahydrocyclohepta[b]pyrazolo[3,4-d]pyridin-3(2h)-one

 CGS 20625 Biological Activity

Description CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures[1].
Related Catalog
Target

IC50: 1.3 nM ([3H]-flunitrazepam binding to central benzodiazepine receptors)[1]

References

[1]. Williams M, et al. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96.

 Chemical & Physical Properties

Density 1.246g/cm3
Boiling Point 503.8ºC at 760mmHg
Molecular Formula C18H19N3O2
Molecular Weight 309.36
Flash Point 258.5ºC
Exact Mass 309.14800
PSA 59.91000
LogP 2.99130
Vapour Pressure 2.82E-10mmHg at 25°C
Index of Refraction 1.617
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