104615-18-1

104615-18-1 structure

Name: CGS 15943
Chemical Name: 9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
CAS Number: 104615-18-1
Molecular Formula: C₁₃H₈ClN₅O
Molecular Weight: 285.68900
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-03-06 20:34:57
Modify Date: 2024-01-09 13:13:47
CGS 15943 is an adenosine A2 receptor antagonist and reduces stroke injury in the Mongolian gerbil[1]. CGS 15943 is a selectively p110γ inhibitor with an IC50 of 1.1 μM, shows inhibitory effect on p110δ (IC50=8.47 μM), has an anti-carcinogenic effect on HCC and PDAC cells[2].

Name	9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Synonyms	MFCD01529897

Description	CGS 15943 is an adenosine A2 receptor antagonist and reduces stroke injury in the Mongolian gerbil[1]. CGS 15943 is a selectively p110γ inhibitor with an IC50 of 1.1 μM, shows inhibitory effect on p110δ (IC50=8.47 μM), has an anti-carcinogenic effect on HCC and PDAC cells[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	p110γ:1.1 μM (IC50) p110δ:8.47 μM (IC50) adenosine A2 receptor
In Vitro	CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[2]. CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells[2]. Cell Viability Assay[2] Cell Line: HLF, SK-Hep-1, HepG2 and PLC-PRF-5 cells Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time: 24 hours Result: Inhibited growth of four distinct HCC cell lines. Western Blot Analysis[2] Cell Line: HLF and Sk-Hep-1 cells Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time: 24 hours Result: Inhibited the PI3K/Akt pathway in HLF and Sk-Hep-1 cells
References	[1]. Gao Y, et al. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55(3):PL61-5. [2]. Edling CE, et al. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15(5):524-32.

Density	1.72 g/cm3
Boiling Point	566.6ºC at 760 mmHg
Melting Point	278-279 °C
Molecular Formula	C₁₃H₈ClN₅O
Molecular Weight	285.68900
Flash Point	296.5ºC
Exact Mass	285.04200
PSA	82.24000
LogP	3.35430
Vapour Pressure	7.4E-13mmHg at 25°C
Index of Refraction	1.84

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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