UCPH-101
Modify Date: 2024-01-12 18:34:51
UCPH-101 structure
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Common Name | UCPH-101 | ||
|---|---|---|---|---|
| CAS Number | 1118460-77-7 | Molecular Weight | 422.47500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H22N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UCPH-101UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. |
| Name | 2-amino-4-(4-methoxyphenyl)-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile |
|---|---|
| Synonym | More Synonyms |
| Description | UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.66 μM (EAAT1)[1] |
| In Vitro | UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048)[1]. |
| Cell Assay | Cells are split into poly-D-lysine-coated black 96-well plates with clear bottom. At 16 to 24 h later, the medium is aspirated, and the cells are washed with 100 μL Krebs buffer [140 mM NaCl/4.7 mM KCl/2.5 mM CaCl2/1.2 mM MgCl2/11 mM HEPES/10 mM D-glucose, pH 7.4]; 50 μL Krebs buffer supplemented with various concentrations of UCPH-101 or TBOA is added to the wells, after which an additional 50 μL Krebs buffer supplemented with the FMP assay dye (1 mg/mL) is added to each well. The plate is incubated at 37°C in a humidified 5% CO2 incubator for 30 min and assayed in a reader measuring emission at 560 nm caused by excitation at 530 nm before and up to 1 min after addition of 33 μL Glu solution[1]. |
| References |
| Molecular Formula | C27H22N2O3 |
|---|---|
| Molecular Weight | 422.47500 |
| Exact Mass | 422.16300 |
| PSA | 85.34000 |
| LogP | 5.75718 |
| Storage condition | 2-8℃ |
| ucph 101 |
| UCPH-101 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: UCPH-101
- Price:
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Tom
- DC Chemicals Limited
- China
- Product Name: UCPH-101
- Price: $550.0/100mg $1000.0/250mg $1950.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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Price: $211/10mM*1mLinDMSO
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