Dynole 34-2

Modify Date: 2024-01-09 20:09:59

Dynole 34-2 structure	Common Name	Dynole 34-2
	CAS Number	1128165-88-7	Molecular Weight	408.58000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₆N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dynole 34-2

Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage[1]. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[2].

Name	(2E)-2-Cyano-3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-N-octy lacrylamide
Synonym	More Synonyms

Description	Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage[1]. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Dynamin
References	[1]. Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10(9):1553-62. [2]. Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52(12):3762-73.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> Dynamin

References

[1]. Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10(9):1553-62.

[2]. Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52(12):3762-73.