Impurity F of Calcipotriol

Modify Date: 2025-08-25 22:08:09

Impurity F of Calcipotriol structure	Common Name	Impurity F of Calcipotriol
	CAS Number	112875-61-3	Molecular Weight	641.12600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₉H₆₈O₃Si₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Impurity F of Calcipotriol

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target:Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Name	(E,1S,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1-cyclopropylpent-2-en-1-ol
Synonym	More Synonyms

Description	Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target:Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Cancer
References	[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240. [2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829. [3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111 [4]. Lise Binderup,, Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895

Description

Related Catalog

Signaling Pathways >> Vitamin D Related >> VD/VDR

Research Areas >> Cancer

References

[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

[2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

[3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

[4]. Lise Binderup,, Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895

Molecular Formula	C₃₉H₆₈O₃Si₂
Molecular Weight	641.12600
Exact Mass	640.47100
PSA	38.69000
LogP	11.14960
InChIKey	DIMYHZDULFSWLS-UHFFFAOYSA-N
SMILES	C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)C=CC(O)C2CC2)CC(O[Si](C)(C)C(C)(C)C)CC1O[Si](C)(C)C(C)(C)C
Storage condition	2-8℃

Precursor 10
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CAS#:18162-48-6 tert-Butyldimet... CAS#:87680-65-7 Vitamin D2 SO2 ... CAS#:247900-07-8 (7Z)-Vitamin D2 CAS#:112828-12-3 (S)-2-((1R,3aS,...
CAS#:112849-18-0 20(R),3(R)-(ter... CAS#:87407-47-4 3(S)-tert-butyl...
DownStream 1
CAS#:112965-21-6 Calcipotriene