Methylergometrine

Modify Date: 2024-01-07 10:35:17

Methylergometrine Structure
Methylergometrine structure
Common Name Methylergometrine
CAS Number 113-42-8 Molecular Weight 339.431
Density 1.3±0.1 g/cm3 Boiling Point 638.4±55.0 °C at 760 mmHg
Molecular Formula C20H25N3O2 Melting Point 172ºC
MSDS N/A Flash Point 339.9±31.5 °C

 Use of Methylergometrine


Methylergometrine (Methylergonovine) is an orally active 5-HT2B ligand agonist. Methylergometrine can be used as oxytocin and has protective effect on postpartum hemorrhage[1][2][3].

 Names

Name Methylergometrine maleate,[8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamidemaleate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 638.4±55.0 °C at 760 mmHg
Melting Point 172ºC
Molecular Formula C20H25N3O2
Molecular Weight 339.431
Flash Point 339.9±31.5 °C
Exact Mass 339.194672
PSA 68.36000
LogP 1.67
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.665

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KE5425000
CHEMICAL NAME :
Ergoline-8-beta-carboxamide, 9,10-didehydro-N-((S)-1-(hydroxymethyl)propyl)-6-meth yl-
CAS REGISTRY NUMBER :
113-42-8
LAST UPDATED :
199509
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C20-H25-N3-O2
MOLECULAR WEIGHT :
339.48
WISWESSER LINE NOTATION :
T C6656 1A P GN LM CUTT&&J EVMY2&1Q G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,163,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,100,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
187 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,163,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,163,1973
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 9,299,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,163,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
10 mg/kg
SEX/DURATION :
female 12-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 180,296,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4271 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 295 (estimated) No. of Female Employees: 243 (estimated)

 Synthetic Route

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Methylergometrine Structure

Methylergometrine

CAS#:113-42-8

Literature: Collection of Czechoslovak Chemical Communications, , vol. 22, p. 1866,1868,1871 Helvetica Chimica Acta, , vol. 26, p. 944,947 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 251, p. 155,160 Collection of Czechoslovak Chemical Communications, , vol. 21, p. 382,386

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Methylergometrine Structure

Methylergometrine

CAS#:113-42-8

Literature: Collection of Czechoslovak Chemical Communications, , vol. 22, p. 1866,1868,1871

~%

Methylergometrine Structure

Methylergometrine

CAS#:113-42-8

Detail
Literature: Collection of Czechoslovak Chemical Communications, , vol. 22, p. 1866,1868,1871

 Synonyms

Methylergobasine
D-Lysergic acid-(+)-butanolamide-(2)
(8β)-N-[(2S)-1-Hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide
Methylergometrin
[8b(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamide
methylergometrine
N-[a-(Hydroxymethyl)propyl]-D-Iysergamide
Methylergobrevin
EINECS 204-027-0
(8β)-N-[(2S)-1-Hydroxy-2-butanyl]-6-methyl-9,10-didehydroergoline-8-carboxamide
D-Lysergic Acid (+)-Butanolamide-(2)
(8β)-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-9,10-didehydroergoline-8-carboxamide
Prestwick_727
Methylergonovine
Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8β)-