(E)-Dosulepin

Modify Date: 2024-01-02 20:22:32

(E)-Dosulepin structure	Common Name	(E)-Dosulepin
	CAS Number	113-53-1	Molecular Weight	295.44
	Density	1.1±0.1 g/cm3	Boiling Point	430.9±44.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₁NS	Melting Point	55-57ºC
	MSDS	N/A	Flash Point	214.4±28.4 °C

Use of (E)-Dosulepin

Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].

Name	dothiepin
Synonym	More Synonyms

Description	Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Histamine H1-receptor, Noradrenaline uptake (α1-and α2-adrenoceptors and serotonin 5HT1 and 5HT2-receptors)[1]
References	[1]. Lancaster SG, et al. Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Jul;38(1):123-47.

Density	1.1±0.1 g/cm3
Boiling Point	430.9±44.0 °C at 760 mmHg
Melting Point	55-57ºC
Molecular Formula	C₁₉H₂₁NS
Molecular Weight	295.44
Flash Point	214.4±28.4 °C
Exact Mass	295.139465
PSA	28.54000
LogP	4.34
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.661

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UI1555000

CHEMICAL NAME :: Propylamine, N,N-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6H), gamma))-

CAS REGISTRY NUMBER :: 113-53-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C19-H21-N-S

MOLECULAR WEIGHT :: 295.47

WISWESSER LINE NOTATION :: T C676 BY IS JHJ BU3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - arrhythmias (including changes in conduction)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 3214 ug/kg/12D-I

TOXIC EFFECTS :: Behavioral - changes in psychophysiological tests

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2143 ug/kg/8D-I

TOXIC EFFECTS :: Behavioral - sleep Behavioral - hallucinations, distorted perceptions Behavioral - changes in psychophysiological tests

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 mg/kg

SEX/DURATION :: male 6 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

REFERENCE :: ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 15,114,1973

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)

11-[3-(dimethyl...

CAS#:1531-85-7

(E)-Dosulepin

CAS#:113-53-1

Literature: WO2007/136743 A2, ; Page/Page column 20-21 ;

Precursor 1
CAS#:1531-85-7 11-[3-(dimethyl...
DownStream 1
CAS#:897-15-4 Dothiepin HCl

1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-, (3E)-

11-(3-Dimethylamino-propyliden)-6,11-dihydro-dibenzo<b.e>thiepin

Methiaden

Dothiepin

Dolsulepine

Dosulepin

Prothiadene

Dosulepine

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin

(3E)-3-(Dibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine

досулепин

iz914

Dothep

trans-dothiepin

Prothiaden

11(16H)-(3-[dimethylamino]propylidene)dibenz[b,e]thiopine

EINECS 204-031-2

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Di-o-tolyl-phosphate-d14
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
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(E)-Dosulepin

Use of (E)-Dosulepin

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(E)-Dosulepin Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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