(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt

Modify Date: 2024-01-10 17:44:21

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt Structure
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt structure
Common Name (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt
CAS Number 114056-26-7 Molecular Weight 1154.401
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C54H79N11O13S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt


(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior[1].

 Names

Name (2S)-N-[(2R)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-amino-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-sulfanylidenepropan-2-yl]-2-[[(2S,3R)-3-hydroxy-2-[[(2S,3S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[2-(1-sulfan
Synonym More Synonyms

  Biological Activity

Description (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior[1].
Related Catalog
Target

Oxytocin[1]

In Vivo (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (50-1000 ng; Intra-MPOA; 1 μL) 抑制大鼠雄性性行为的某些方面[1]。 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (100 ng; i.c.v.; 1 μL) 可有效抑制雄性大鼠交配行为后的痛觉减退[2]。 Animal Model: Adult Long–Evans/Blue-Spruce rats[1] Dosage: 50 ng, 200 ng, and 1 μg Administration: Intra-MPOA (medial preoptic area) injection, 1 μL Result: Significantly increased intromission latency and anogenital investigation at 1 μg dose. Significantly decreased intromission ratio (2) at all doses. Animal Model: Adult male and female Long-Evans rats (8 weeks old, 220–260 g BW)[2] Dosage: 100 ng Administration: Intracerebroventricular injection, 1 μL Result: Was effective in reducing pain threshold heightened by copulatory behavior.
References

[1]. Gil M, et al. Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat. Horm Behav. 2011 Apr;59(4):435-43.  

[2]. Futagami H, et al. Oxytocin mediates copulation-induced hypoalgesia of male rats. Neurosci Lett. 2016 Apr 8;618:122-126.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C54H79N11O13S2
Molecular Weight 1154.401
Exact Mass 1153.530029
PSA 483.20000
LogP 3.80
Index of Refraction 1.633

 Synonyms

OVTA
N-[(1-Sulfanylcyclohexyl)acetyl]-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-3-thioxo-L-alanyl-L-prolyl-L-ornithyl-O-methyl-L-tyrosinamide
L-Tyrosinamide, N-[2-(1-mercaptocyclohexyl)acetyl]-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-3-thioxo-L-alanyl-L-prolyl-L-ornithyl-O-methyl-
Ota-vasotocin
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