Bromo-PEG3-phosphonic acid diethyl ester

Modify Date: 2024-01-02 19:54:22

Bromo-PEG3-phosphonic acid diethyl ester Structure
Bromo-PEG3-phosphonic acid diethyl ester structure
Common Name Bromo-PEG3-phosphonic acid diethyl ester
CAS Number 1148026-98-5 Molecular Weight 377.209
Density 1.3±0.1 g/cm3 Boiling Point 426.5±35.0 °C at 760 mmHg
Molecular Formula C12H26BrO6P Melting Point N/A
MSDS N/A Flash Point 211.7±25.9 °C

 Use of Bromo-PEG3-phosphonic acid diethyl ester


Bromo-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Diethyl (2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethyl)phosphonate
Synonym More Synonyms

 Bromo-PEG3-phosphonic acid diethyl ester Biological Activity

Description Bromo-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 426.5±35.0 °C at 760 mmHg
Molecular Formula C12H26BrO6P
Molecular Weight 377.209
Flash Point 211.7±25.9 °C
Exact Mass 376.065033
LogP -0.02
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.460

 Synonyms

Diethyl (2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethyl)phosphonate
Phosphonic acid, P-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]-, diethyl ester
MFCD11982880