Oxyphenisatin acetate

Modify Date: 2026-07-10 15:47:04

Oxyphenisatin acetate structure	Common Name	Oxyphenisatin acetate
	CAS Number	115-33-3	Molecular Weight	401.41100
	Density	1.282 g/cm3	Boiling Point	566.5ºC at 760 mmHg
	Molecular Formula	C₂₄H₁₉NO₅	Melting Point	244℃
	MSDS	N/A	Flash Point	296.4ºC

Use of Oxyphenisatin acetate

Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	[4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others
In Vitro	Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1].
In Vivo	Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model[1].
Animal Admin	Assessment in several other tumor models demonstrates tolerability with oxyphenisatin acetate at 300 mg/kg given once daily or 200 mg/kg given twice daily. For the MCF-7 study treatments are administered on an exact body weight basis using dose volumes of 1-2 mL/kg body weight. The vehicle control receives 100% DMSO. The treated group receives 300 mg/kg oxyphenisatin acetate once daily for a total of 10 days, followed by a 3 day rest and an additional 6 days of dosing. The dose solutions are prepared in 100% DMSO, aliquoted and stored frozen until used. The mice are monitored for a total of 52 days with treatment initiation occurring on day 27 posttumor implantation[1].
References	[1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.282 g/cm3
Boiling Point	566.5ºC at 760 mmHg
Melting Point	244℃
Molecular Formula	C₂₄H₁₉NO₅
Molecular Weight	401.41100
Flash Point	296.4ºC
Exact Mass	401.12600
PSA	81.70000
LogP	3.96170
Vapour Pressure	7.5E-13mmHg at 25°C
Index of Refraction	1.611
InChIKey	PHPUXYRXPHEJDF-UHFFFAOYSA-N
SMILES	CC(=O)Oc1ccc(C2(c3ccc(OC(C)=O)cc3)C(=O)Nc3ccccc32)cc1
Storage condition	2-8℃

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2933790090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Oxyphenisatine

CAS#:125-13-3

Oxyphenisatin a...

CAS#:115-33-3

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Literature: Nakazawa; Matsuura Yakugaku Zasshi, 1954 , vol. 74, p. 69 Chem.Abstr., 1955 , p. 1631

isatin

CAS#:91-56-5

phenyl acetate

CAS#:122-79-2

Oxyphenisatin a...

CAS#:115-33-3

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Literature: Inagaki; Nakato Yakugaku Zasshi, 1933 , vol. 53, p. 719,722; dtsch. Ref. S. 134 Chem.Abstr., 1934 , p. 2003

Oxyphenisatine

CAS#:125-13-3

Ethanoic anhydride

CAS#:108-24-7

Oxyphenisatin a...

CAS#:115-33-3

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Literature: Hoffmann-La Roche and Co. Patent: DE406210 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 1412 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE447539 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1693 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE482435 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2519

Oxyphenisatine

CAS#:125-13-3

acetic acid

CAS#:64-19-7

Oxyphenisatin a...

CAS#:115-33-3

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Oxyphenisatine

CAS#:125-13-3

Acetyl chloride

CAS#:75-36-5

Oxyphenisatin a...

CAS#:115-33-3

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AKOS BBS-00005529

CAS#:39033-45-9

phenyl acetate

CAS#:122-79-2

Oxyphenisatin a...

CAS#:115-33-3

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Literature: Inagaki Yakugaku Zasshi, 1933 , vol. 53, p. 686,696;dtsch.Ref.S.133 Chem. Zentralbl., 1933 , vol. 104, # II p. 2133

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 7
CAS#:125-13-3 Oxyphenisatine CAS#:91-56-5 isatin CAS#:122-79-2 phenyl acetate CAS#:108-24-7 Ethanoic anhydride
CAS#:64-19-7 acetic acid CAS#:75-36-5 Acetyl chloride CAS#:39033-45-9 AKOS BBS-00005529
DownStream 0

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve...
Source: NCGC
Target: N/A
External Id: OBG420

Total 259, Current Page 1 of 26

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

3,3-bis-(4-acetoxy-phenyl)-indolin-2-one

Izafenin

3,3-bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one

Darmoletten

Diphesatine

Acetalax

Contax

Promassolax

3,3-bis(4-acetoxyphenyl)oxindole

Brocatine

Isaphenin

OXYPHENISATIN ACETATE

EINECS 204-083-6

Diphesatin

3,3-Bis-(4-acetoxy-phenyl)-indolin-2-on

oxyphenisatine di(acetate)

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: Boiling point of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate is 566.5ºC at 760 mmHg.

Q: What are the uses of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: Main uses of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate: Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative.

Q: What are the storage conditions for [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: Storage conditions for [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate: 2-8℃.

Q: What is the English name of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: The English name of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate is [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate.

Q: What is the molecular weight of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: Molecular weight of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate is 401.41100.

Q: What is the polar surface area (PSA) of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: Polar surface area (PSA) of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate is 81.70000.

Q: What English synonyms does [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate have?

A: English synonyms of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate: 3,3-bis-(4-acetoxy-phenyl)-indolin-2-one, Izafenin, 3,3-bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one, Darmoletten, Diphesatine, Acetalax, Contax, Promassolax, 3,3-bis(4-acetoxyphenyl)oxindole, Brocatine, Isaphenin, OXYPHENISATIN ACETATE, EINECS 204-083-6, Diphesatin, 3,3-Bis-(4-acetoxy-phenyl)-indolin-2-on, oxyphenisatine di(acetate).

Q: What is the melting point of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: Melting point of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate is 244℃.

Q: What is the LogP of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: LogP of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate is 3.96170.

Q: What is the CAS number of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate?

A: CAS number of [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate is 115-33-3.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Oxyphenisatinacetate
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2H-Indol-2-one,3,3-bis[4-(acetyloxy)phenyl]-1,3-dihydro-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $66/10mM*1mLinDMSO

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.