2-chloro-3'-deoxyadenosine

Modify Date: 2024-01-09 16:37:43

2-chloro-3'-deoxyadenosine Structure
2-chloro-3'-deoxyadenosine structure
 Common Name 2-chloro-3'-deoxyadenosine
CAS Number 115044-75-2 Molecular Weight 285.69
Density 2.03g/cm3 Boiling Point 547.6ºC at 760mmHg
Molecular Formula C10H12ClN5O3 Melting Point N/A
MSDS N/A Flash Point 285ºC

 Use of 2-chloro-3'-deoxyadenosine


2-Chloro-3′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name (2R,3R,5S)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
Synonym More Synonyms

 2-chloro-3'-deoxyadenosine Biological Activity

Description 2-Chloro-3′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.03g/cm3
Boiling Point 547.6ºC at 760mmHg
Molecular Formula C10H12ClN5O3
Molecular Weight 285.69
Flash Point 285ºC
Exact Mass 285.06300
PSA 119.31000
LogP 0.28380
Vapour Pressure 7.95E-13mmHg at 25°C
Index of Refraction 1.87

 Synthetic Route

((2S,4R,5R)-4-acetoxy-5-(6-amino-2-chloro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl benzoate structure

((2S,4R,5R)-4-a...

CAS#:1504571-49-6

~36%

2-chloro-3'-deoxyadenosine Structure

2-chloro-3'-deo...

CAS#:115044-75-2
Literature: Vodnala, Suman K.; Lundbaeck, Thomas; Yeheskieli, Esther; Sjoeberg, Birger; Gustavsson, Anna-Lena; Svensson, Richard; Olivera, Gabriela C.; Eze, Anthonius A.; De Koning, Harry P.; Hammarstroem, Lars G. J.; Rottenberg, Martin E. Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9861 - 9873
2-Chloroadenosine structure

2-Chloroadenosine

CAS#:146-77-0

~%

2-chloro-3'-deoxyadenosine Structure

2-chloro-3'-deo...

CAS#:115044-75-2
Literature: Rosowsky, Andre; Solan, Vishnu C.; Sodroski, Joseph G.; Ruprecht, Ruth M. Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1135 - 1140
N/A structure

N/A

CAS#:119530-57-3

~%

2-chloro-3'-deoxyadenosine Structure

2-chloro-3'-deo...

CAS#:115044-75-2
Literature: Rosowsky, Andre; Solan, Vishnu C.; Sodroski, Joseph G.; Ruprecht, Ruth M. Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1135 - 1140
2-chloroadenine structure

2-chloroadenine

CAS#:1839-18-5
β-D-erythro-Pentofuranose, 3-deoxy-, 1,2-diacetate 5-benzoate structure

β-D-erythro-Pen...

CAS#:90580-88-4

~%

2-chloro-3'-deoxyadenosine Structure

2-chloro-3'-deo...

CAS#:115044-75-2
Literature: Vodnala, Suman K.; Lundbaeck, Thomas; Yeheskieli, Esther; Sjoeberg, Birger; Gustavsson, Anna-Lena; Svensson, Richard; Olivera, Gabriela C.; Eze, Anthonius A.; De Koning, Harry P.; Hammarstroem, Lars G. J.; Rottenberg, Martin E. Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9861 - 9873
N/A structure

N/A

CAS#:119530-58-4

~%

2-chloroadenine structure

2-chloroadenine

CAS#:1839-18-5
2-chloro-3'-deoxyadenosine Structure

2-chloro-3'-deo...

CAS#:115044-75-2

N/A structure

N/A

CAS#:119530-61-9
Literature: Rosowsky, Andre; Solan, Vishnu C.; Sodroski, Joseph G.; Ruprecht, Ruth M. Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1135 - 1140

 Synonyms

biodribin
C10H14ClN5O3
Adenosine,2-chloro-3'-deoxy
2-Chloro-3'-deoxyadenosine
2-chlorocordycepin
3'-Deoxy-2-chloroadenosine
UNII-JYW18Y92UP
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