Tetrachlorophthalic anhydride

Modify Date: 2026-07-01 11:37:01

Tetrachlorophthalic anhydride Structure
Tetrachlorophthalic anhydride structure
 Common Name Tetrachlorophthalic anhydride
CAS Number 117-08-8 Molecular Weight 285.896
Density 1.9±0.1 g/cm3 Boiling Point 371.0±0.0 °C at 760 mmHg
Molecular Formula C8Cl4O3 Melting Point 253-257 °C(lit.)
MSDS Chinese USA Flash Point 161.6±25.5 °C
Symbol GHS05 GHS08 GHS09
GHS05, GHS08, GHS09		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name tetrachlorophthalic anhydride
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.9±0.1 g/cm3
Boiling Point 371.0±0.0 °C at 760 mmHg
Melting Point 253-257 °C(lit.)
Molecular Formula C8Cl4O3
Molecular Weight 285.896
Flash Point 161.6±25.5 °C
Exact Mass 283.860168
PSA 43.37000
LogP 3.56
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.656
InChIKey AUHHYELHRWCWEZ-UHFFFAOYSA-N
SMILES O=C1OC(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c21
Stability Stable. Reacts with water. Combustible. Incompatible with strong oxidizing agents. Air and moisture sensitive.
Water Solubility 0.8 mg/L (21 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TI3450000
CHEMICAL NAME :
Phthalic anhydride, tetrachloro-
CAS REGISTRY NUMBER :
117-08-8
BEILSTEIN REFERENCE NO. :
0211560
LAST UPDATED :
199712
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C8-Cl4-O3
MOLECULAR WEIGHT :
285.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3600 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
68250 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/m3/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight Endocrine - hyperglycemia Blood - changes in leukocyte (WBC) count
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538630 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3316 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 142 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3316 No. of Facilities: 43 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 2067 (estimated) No. of Female Employees: 786 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS05 GHS08 GHS09
GHS05, GHS08, GHS09
Signal Word Danger
Hazard Statements H317-H318-H334-H350-H373-H410
Precautionary Statements P201-P261-P273-P280-P305 + P351 + P338-P308 + P313
Hazard Codes T:Toxic
Risk Phrases R41;R42/43;R45;R50/53
Safety Phrases S53-S22-S24-S26-S37/39-S45-S60-S61
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS TI3450000
Packaging Group III
Hazard Class 9
HS Code 2917399090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles13

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Allergic reactions to industrial chemicals.

Clin. Immunol. Rev. 2(1) , 1-58, (1983)

Acid anhydrides.

Clin. Exp. Allergy 21 Suppl 1 , 234-40, (1991)

Immunologic specificity of IgG against trimellityl-human serum albumin in serum samples of workers exposed to trimellitic anhydride.

J. Lab. Clin. Med. 121(6) , 792-6, (1993)

The specificity of immunoglobulin G (IgG) against trimellityl-human serum albumin (TM-HSA) in serum samples from 11 workers exposed to trimellitic anhydride (TMA) was characterized in this study. Leve...

 Tetrachlorophthalic anhydrideBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4,5,6,7-Tetrachloro-1,3-isobenzofurandione
Tetrachlorophthalic anhydride
4,5,6,7-Tetrachloro-2-benzofuran-1,3-dione
MFCD00005920
EINECS 204-171-4

 Tetrachlorophthalic anhydride | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of tetrachlorophthalic anhydride?
A: LogP of tetrachlorophthalic anhydride is 3.56.
Q: What is the CAS number of tetrachlorophthalic anhydride?
A: CAS number of tetrachlorophthalic anhydride is 117-08-8.
Q: What is the molecular formula of tetrachlorophthalic anhydride?
A: Molecular formula of tetrachlorophthalic anhydride is C8Cl4O3.
Q: What English synonyms does tetrachlorophthalic anhydride have?
A: English synonyms of tetrachlorophthalic anhydride: 4,5,6,7-Tetrachloro-1,3-isobenzofurandione, Tetrachlorophthalic anhydride, 4,5,6,7-Tetrachloro-2-benzofuran-1,3-dione, MFCD00005920, EINECS 204-171-4.
Q: What is the polar surface area (PSA) of tetrachlorophthalic anhydride?
A: Polar surface area (PSA) of tetrachlorophthalic anhydride is 43.37000.
Q: What is the boiling point of tetrachlorophthalic anhydride?
A: Boiling point of tetrachlorophthalic anhydride is 371.0±0.0 °C at 760 mmHg.
Q: What is the English name of tetrachlorophthalic anhydride?
A: The English name of tetrachlorophthalic anhydride is tetrachlorophthalic anhydride.
Q: What is the melting point of tetrachlorophthalic anhydride?
A: Melting point of tetrachlorophthalic anhydride is 253-257 °C(lit.).
Q: How is the water solubility of tetrachlorophthalic anhydride?
A: Water solubility of tetrachlorophthalic anhydride: 0.8 mg/L (21 ºC).
Q: What is the SMILES notation of tetrachlorophthalic anhydride?
A: SMILES notation of tetrachlorophthalic anhydride is O=C1OC(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c21.

 Tetrachlorophthalic anhydridefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides Tetrachlorophthalic anhydride(CAS#:117-08-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tetrachlorophthalic anhydride are included as well.>> amp version: Tetrachlorophthalic anhydride

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