Eteplirsen

Modify Date: 2024-01-04 20:24:58

Eteplirsen Structure
Eteplirsen structure
Common Name Eteplirsen
CAS Number 1173755-55-9 Molecular Weight 10305.74000
Density N/A Boiling Point N/A
Molecular Formula C364H569N177O122P30 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Eteplirsen


Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide. Eteplirsen can be used for Duchenne muscular dystrophy research[1].

 Names

Name Eteplirsen
Synonym More Synonyms

 Eteplirsen Biological Activity

Description Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide. Eteplirsen can be used for Duchenne muscular dystrophy research[1].
Related Catalog
In Vitro Eteplirsen acts to promote dystrophin production by restoring the translational reading frame of Duchenne muscular dystrophy (DMD) through specific skipping of exon 51 in defective gene variants[1].
References

[1]. Kenji Rowel Q Lim, et al. Eteplirsen in the treatment of Duchenne muscular dystrophy. Drug Des Devel Ther. 2017 Feb 28;11:533-545.

 Chemical & Physical Properties

Molecular Formula C364H569N177O122P30
Molecular Weight 10305.74000
Exact Mass 10300.59000

 Synonyms

AVI-4658
Exondys 51
(P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl)-1-piperazinyl)-N,N-dimethylphosphonamidate) RNA