TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID

Modify Date: 2024-01-01 21:50:25

TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID Structure
TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID structure
Common Name TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID
CAS Number 117488-23-0 Molecular Weight 159.14000
Density 1.568g/cm3 Boiling Point 288.1ºC at 760mmHg
Molecular Formula C6H9NO4 Melting Point N/A
MSDS N/A Flash Point 128ºC

 Use of TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID


trans-ACBD (trans-1-Aminocyclobutane-1,3-dicarboxylic acid) is a very potent and selective NMDA receptor agonist that modulates glutamatergic neurotransmission[1].

 Names

Name 1-aminocyclobutane-cis-1,3-dicarboxylic acid
Synonym More Synonyms

  Biological Activity

Description trans-ACBD (trans-1-Aminocyclobutane-1,3-dicarboxylic acid) is a very potent and selective NMDA receptor agonist that modulates glutamatergic neurotransmission[1].
Related Catalog
References

[1]. Dimpfel W, et al. Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro. BMC Pharmacol. 2011 Feb 21;11:2.  

 Chemical & Physical Properties

Density 1.568g/cm3
Boiling Point 288.1ºC at 760mmHg
Molecular Formula C6H9NO4
Molecular Weight 159.14000
Flash Point 128ºC
Exact Mass 159.05300
PSA 100.62000
Vapour Pressure 0.000607mmHg at 25°C
Index of Refraction 1.587

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU1690000
CHEMICAL NAME :
1,3-Cyclobutanedicarboxylic acid, 1-amino-, trans-, hydrate
CAS REGISTRY NUMBER :
117488-23-0
LAST UPDATED :
199109
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H9-N-O4.H2-O
MOLECULAR WEIGHT :
177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990

 Synonyms

trans-1-aminocyclobutane-1,3-dicarboxylic acid
cis-2,4-methanoglutamate
1-aminocyclobutyl carboxylic acid methyl ester
1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER
trans-2,4-methanoglutamic acid
methyl 1-amino-cyclobutanecarboxylate
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