Pseudouridine 5'-triphosphate

Modify Date: 2024-01-09 19:32:47

Pseudouridine 5'-triphosphate structure	Common Name	Pseudouridine 5'-triphosphate
	CAS Number	1175-34-4	Molecular Weight	484.14100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉H₁₅N₂O₁₅P₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pseudouridine 5'-triphosphate

pseudouridine-5’-triphosphate (Pseudo-UTP) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties.

Name	(1S)-1,4-Anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-5 -O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-D-ri bitol
Synonym	More Synonyms

Description	pseudouridine-5’-triphosphate (Pseudo-UTP) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Shanmugasundaram M, Senthilvelan A, Kore AR. Gram-Scale Chemical Synthesis of Base-Modified Ribonucleoside-5'-O-Triphosphates. Curr Protoc Nucleic Acid Chem. 2016;67:13.15.1-13.15.10. [2]. Borchardt EK, Martinez NM, Gilbert WV. Regulation and Function of RNA Pseudouridylation in Human Cells. Annu Rev Genet. 2020;54:309-336. [3]. Anderson BR, Muramatsu H, Nallagatla SR, et al. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res. 2010;38(17):5884-5892.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Shanmugasundaram M, Senthilvelan A, Kore AR. Gram-Scale Chemical Synthesis of Base-Modified Ribonucleoside-5'-O-Triphosphates. Curr Protoc Nucleic Acid Chem. 2016;67:13.15.1-13.15.10.

[2]. Borchardt EK, Martinez NM, Gilbert WV. Regulation and Function of RNA Pseudouridylation in Human Cells. Annu Rev Genet. 2020;54:309-336.

[3]. Anderson BR, Muramatsu H, Nallagatla SR, et al. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res. 2010;38(17):5884-5892.