Bicyclol
Modify Date: 2024-01-04 11:19:38
Bicyclol structure
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Common Name | Bicyclol | ||
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| CAS Number | 118159-48-1 | Molecular Weight | 390.34100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H18O9 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of BicyclolBicyclol(SY 801) is a anti-hepatitis drug.Target: HBVOral administration of bicyclol normalized the elevated serum transaminases (ALT, AST) by approximately 50% in chronic viral hepatitis B and C, and also showed certain level of inhibiting HBV and HCV replication. No noticeable adverse reaction has been observed. In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may potentiate the anti-viral efficacy and reduce YMDD mutant and side effects. In 2004 China FDA issued license to manufacture bicyclol. Since then bicyclol has been widely used to treat chronic HBV and HCV in China [1]. |
| Name | methyl 4-[5-(hydroxymethyl)-7-methoxy-1,3-benzodioxol-4-yl]-7-methoxy-1,3-benzodioxole-5-carboxylate |
|---|---|
| Synonym | More Synonyms |
| Description | Bicyclol(SY 801) is a anti-hepatitis drug.Target: HBVOral administration of bicyclol normalized the elevated serum transaminases (ALT, AST) by approximately 50% in chronic viral hepatitis B and C, and also showed certain level of inhibiting HBV and HCV replication. No noticeable adverse reaction has been observed. In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may potentiate the anti-viral efficacy and reduce YMDD mutant and side effects. In 2004 China FDA issued license to manufacture bicyclol. Since then bicyclol has been widely used to treat chronic HBV and HCV in China [1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C19H18O9 |
|---|---|
| Molecular Weight | 390.34100 |
| Exact Mass | 390.09500 |
| PSA | 101.91000 |
| LogP | 2.10710 |
| Storage condition | 2-8℃ |
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A sexual dimorphism influences bicyclol-induced hepatic heat shock factor 1 activation and hepatoprotection.
Mol. Pharmacol. 88 , 38-47, (2015) Bicyclol [4,4'-dimethoxy-5,6,5',6'-bis(methylenedioxy)-2-hydroxy-methyl-2'-methoxycarbonyl biphenyl] is a synthetic hepatoprotectant widely used in clinical practice, but resistance to this treatment ... |
| bicyclol |