Omidenepag isopropyl

Modify Date: 2024-01-02 18:52:37

Omidenepag isopropyl structure	Common Name	Omidenepag isopropyl
	CAS Number	1187451-19-9	Molecular Weight	520.603
	Density	1.3±0.1 g/cm3	Boiling Point	709.9±70.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₂₈N₆O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	383.1±35.7 °C

Use of Omidenepag isopropyl

Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. Other Indication Preregistration

Name	Omidenapag isopropyl
Synonym	More Synonyms

Description	Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. Other Indication Preregistration
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	EP2
In Vivo	Omidenepag isopropyl at 0.0001%, 0.001%, or 0.01%, Xalatan, or vehicle was topically administered to one eye in ocular normotensive monkeys. IOP change after drug administration was compared to the predosing baseline value established on day 1. Omidenepag isopropyl also shows significant and dose-dependent IOP-lowering effects at doses of 0.0001%, 0.001%, and 0.01% in ocular normotensive monkeys, with mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg at each tested concentration, respectively. The significant decreases in IOP for 0.001% and 0.01% OMDI at time 0 of day 7. Omidenepag isopropyl is hydrolyzed in the eye to Omidenepag (OMD), an EP2 receptor agonist , with a significant ocular hypotensive effect in both ocular normotensive and hypertensive animal models[1]. In ocular hypertensive monkeys finds that Omidenepag isopropyl lowers IOP by increasing both trabecular outflow facility and uveoscleral outflow[2].
References	[1]. Kirihara T, et al. Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):145-153. [2]. Fuwa M, et al. Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys. J Ocul Pharmacol Ther. 2018 Sep;34(7):531-537.

Density	1.3±0.1 g/cm3
Boiling Point	709.9±70.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₈N₆O₄S
Molecular Weight	520.603
Flash Point	383.1±35.7 °C
Exact Mass	520.189270
LogP	3.26
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.641