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1187451-19-9

1187451-19-9 structure
1187451-19-9 structure
  • Name: Omidenepag isopropyl
  • Chemical Name: Omidenapag isopropyl
  • CAS Number: 1187451-19-9
  • Molecular Formula: C26H28N6O4S
  • Molecular Weight: 520.603
  • Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
  • Create Date: 2020-01-11 21:58:50
  • Modify Date: 2024-01-02 18:52:37
  • Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. Other Indication Preregistration
Name Omidenapag isopropyl
Synonyms DE-117
Isopropyl N-[6-({[4-(1H-pyrazol-1-yl)benzyl](3-pyridinylsulfonyl)amino}methyl)-2-pyridinyl]glycinate
G0G0H52U6K
Omidenapag isopropyl
Glycine, N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]-2-pyridinyl]-, 1-methylethyl ester
OMIDENEPAG ISOPROPYL
UNII-G0G0H52U6K
Description Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. Other Indication Preregistration
Related Catalog
Target

EP2

In Vivo Omidenepag isopropyl at 0.0001%, 0.001%, or 0.01%, Xalatan, or vehicle was topically administered to one eye in ocular normotensive monkeys. IOP change after drug administration was compared to the predosing baseline value established on day 1. Omidenepag isopropyl also shows significant and dose-dependent IOP-lowering effects at doses of 0.0001%, 0.001%, and 0.01% in ocular normotensive monkeys, with mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg at each tested concentration, respectively. The significant decreases in IOP for 0.001% and 0.01% OMDI at time 0 of day 7. Omidenepag isopropyl is hydrolyzed in the eye to Omidenepag (OMD), an EP2 receptor agonist , with a significant ocular hypotensive effect in both ocular normotensive and hypertensive animal models[1]. In ocular hypertensive monkeys finds that Omidenepag isopropyl lowers IOP by increasing both trabecular outflow facility and uveoscleral outflow[2].
References

[1]. Kirihara T, et al. Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):145-153.

[2]. Fuwa M, et al. Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys. J Ocul Pharmacol Ther. 2018 Sep;34(7):531-537.

Density 1.3±0.1 g/cm3
Boiling Point 709.9±70.0 °C at 760 mmHg
Molecular Formula C26H28N6O4S
Molecular Weight 520.603
Flash Point 383.1±35.7 °C
Exact Mass 520.189270
LogP 3.26
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.641

Chemsrc provides CAS#:1187451-19-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 1187451-19-9 | Chemsrc address: https://m.chemsrc.com/en/baike/1559914.html

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