5-Fluorouracil-13C,15N2

Modify Date: 2024-01-06 11:09:26

5-Fluorouracil-13C,15N2 structure	Common Name	5-Fluorouracil-13C,15N2
	CAS Number	1189423-58-2	Molecular Weight	133.057
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₁₃CH₃F₁₅N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5-Fluorouracil-13C,15N2

5-Fluorouracil-13C,15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

Name	5-Fluorouracil-13C,15N2
Synonym	More Synonyms

Description	5-Fluorouracil-13C,15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Han R, et al. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and NSC 123127 for enhanced therapeutic efficacy. J Drug Target. 2016 Jun 29:1-28. [Epub ahead of print] [3]. McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil. 2016 Jun 28. [4]. Zeng Q, et al. Knockdown of NFBD1/MDC1 enhances chemosensitivity to NSC 119875 or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells. Mol Cell Biochem. 2016 Jul418(1-2):137-46. [5]. Yin L, et al. Antitumor effects of oncolytic herpes simplex virus type 2 against colorectal cancer in vitro and in vivo. Ther Clin Risk Manag. 2017 Feb 713:117-130. [6]. Jones DH, et al. Ten-Year and Beyond Follow-up After Treatment With Highly Purified Liquid-Injectable Silicone for HIV-Associated Facial Lipoatrophy: A Report of 164 Patients. Dermatol Surg. 2019 Jul45(7):941-948. [7]. Snyder SM, et al. Initial Experience with Topical Fluorouracil for Treatment of HIV-Associated Anal Intraepithelial Neoplasia. J Int Assoc Physicians AIDS Care (Chic). 201110(2):83-88. [8]. Pek Yee Lum, et al. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell. 2004 Jan 9116(1):121-37.

Density	1.5±0.1 g/cm3
Molecular Formula	C₃₁₃CH₃F₁₅N₂O₂
Molecular Weight	133.057
Exact Mass	133.015274
Index of Refraction	1.523

5-Fluorouracil-2-13C,15N2

MFCD09840633

2,4(1H,3H)-Pyrimidinedione-2-13C-1,3-15N2, 5-fluoro-

5-Fluorouracil-13C,15N2

5-Fluoro-2,4(1H,3H)-(2-13C,15N2)pyrimidinedione

5-Fluorouracil-13C,15N2

Use of 5-Fluorouracil-13C,15N2

Names

5-Fluorouracil-13C,15N2 Biological Activity

Chemical & Physical Properties

Synonyms