Bezafibrate-d4

Modify Date: 2024-01-16 09:17:54

Bezafibrate-d4 structure	Common Name	Bezafibrate-d4
	CAS Number	1189452-53-6	Molecular Weight	365.84
	Density	1.3±0.1 g/cm3	Boiling Point	572.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₁₆D₄ClNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	299.8±28.7 °C

Use of Bezafibrate-d4

Bezafibrate-d4 is deuterium labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.

Name	Bezafibrate
Synonym	More Synonyms

Description	Bezafibrate-d4 is deuterium labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [3]. Usui-Ouchi A, et al. The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells. Int Immunopharmacol. 2017 Nov;52:70-76. [4]. Franko A, et al. Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. Mol Metab. 2017 Jan 6;6(3):256-266.

Density	1.3±0.1 g/cm3
Boiling Point	572.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₆D₄ClNO₄
Molecular Weight	365.84
Flash Point	299.8±28.7 °C
Exact Mass	361.108093
LogP	3.46
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.583